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Title: A Trait-Based Approach to Predicting Viral Host-Range Evolvability
Predicting the evolution of virus host range has proven to be extremely difficult, in part because of the sheer diversity of viruses, each with unique biology and ecological interactions. We have not solved this problem, but to make the problem more tractable, we narrowed our focus to three traits intrinsic to all viruses that may play a role in host-range evolvability: mutation rate, recombination rate, and phenotypic heterogeneity. Although each trait should increase evolvability, they cannot do so unbounded because fitness trade-offs limit the ability of all three traits to maximize evolvability. By examining these constraints, we can begin to identify groups of viruses with suites of traits that make them especially concerning, as well as ecological and environmental conditions that might push evolution toward accelerating host-range expansion.  more » « less
Award ID(s):
1934515
PAR ID:
10556587
Author(s) / Creator(s):
; ;
Publisher / Repository:
Annual Reviews Open Access
Date Published:
Journal Name:
Annual Review of Virology
Volume:
9
Issue:
1
ISSN:
2327-056X
Page Range / eLocation ID:
139 to 156
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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