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Abstract Detection and identification of chiral molecules are important for pharmaceutical industry, clinical analysis, and food analysis. Here, chiral molecular sensing based on spatially selective coupling between achiral metasurface and chiral molecules is demonstrated. The designed achiral metasurface exhibits strong optical chirality and electric field with dissymmetric distribution, and chiral molecules are selectively placed over the area with large optical chirality to form the coupled metasurface-molecule system with circular dichroism (CD) response for chiral molecular sensing. The CD spectra of the metasurface coupled with pure D-alanine enantiomer, L-alanine enantiomer and their mixtures are examined. The linear relationship between the peak CD value and the enantiomeric excess is demonstrated for the detection and identification of pure enantiomers and their mixtures. Furthermore, the CD response of the coupled system shows potential for the sensing of molar concentration of chiral molecules. Moreover, the effect of spatial location of molecules on the CD response is analyzed to show potential for position sensing of chiral molecules. These results of chiral molecular sensing with achiral metasurface offer new opportunities for advancing biomolecular sensing applications.
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Circular dichroism in achiral metasurfaces induced by spatially selective coupling with molecules
Achiral metasurfaces with near-field optical chirality have attracted great attention in molecular sensing and chiral emission control. Here, the circular dichroism (CD) response of an achiral metasurface induced by spatially selective coupling with polymethyl methacrylate (PMMA) molecules is demonstrated. A designed achiral metasurface with a V-shaped resonator exhibits large optical chirality with a strongly dissymmetric distribution under circular polarization. By introducing a PMMA molecule layer on top of the metasurface, which covers the area with large optical chirality, CD in absorption of 0.38 and a dissymmetric factor of optical chiralitygcof 0.16 are obtained. Furthermore, an analysis of the coupled harmonic oscillator model reveals stronger coupling strength between the PMMA layer and the metasurface under RCP incidence, compared to the LCP case. Moreover, it is shown that the far-field CD response of the metasurface is linearly correlated with the dissymmetric near-field optical chirality distribution. The demonstrated results present the potential for advancing applications in chiral molecule vibrational sensing, thermal emission control, and infrared chiral imaging.
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- PAR ID:
- 10565520
- Publisher / Repository:
- Optical Society of America
- Date Published:
- Journal Name:
- Optics Letters
- Volume:
- 50
- Issue:
- 2
- ISSN:
- 0146-9592; OPLEDP
- Format(s):
- Medium: X Size: Article No. 399
- Size(s):
- Article No. 399
- Sponsoring Org:
- National Science Foundation
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