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Abstract MotivationBreast cancer is a type of cancer that develops in breast tissues, and, after skin cancer, it is the most commonly diagnosed cancer in women in the United States. Given that an early diagnosis is imperative to prevent breast cancer progression, many machine learning models have been developed in recent years to automate the histopathological classification of the different types of carcinomas. However, many of them are not scalable to large-scale datasets. ResultsIn this study, we propose the novel Primal-Dual Multi-Instance Support Vector Machine to determine which tissue segments in an image exhibit an indication of an abnormality. We derive an efficient optimization algorithm for the proposed objective by bypassing the quadratic programming and least-squares problems, which are commonly employed to optimize Support Vector Machine models. The proposed method is computationally efficient, thereby it is scalable to large-scale datasets. We applied our method to the public BreaKHis dataset and achieved promising prediction performance and scalability for histopathological classification. Availability and implementationSoftware is publicly available at: https://1drv.ms/u/s!AiFpD21bgf2wgRLbQq08ixD0SgRD?e=OpqEmY. Supplementary informationSupplementary data are available at Bioinformatics online.
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This content will become publicly available on December 1, 2025
Employing Raman Spectroscopy and Machine Learning for the Identification of Breast Cancer
Abstract BackgroundBreast cancer poses a significant health risk to women worldwide, with approximately 30% being diagnosed annually in the United States. The identification of cancerous mammary tissues from non-cancerous ones during surgery is crucial for the complete removal of tumors. ResultsOur study innovatively utilized machine learning techniques (Random Forest (RF), Support Vector Machine (SVM), and Convolutional Neural Network (CNN)) alongside Raman spectroscopy to streamline and hasten the differentiation of normal and late-stage cancerous mammary tissues in mice. The classification accuracy rates achieved by these models were 94.47% for RF, 96.76% for SVM, and 97.58% for CNN, respectively. To our best knowledge, this study was the first effort in comparing the effectiveness of these three machine-learning techniques in classifying breast cancer tissues based on their Raman spectra. Moreover, we innovatively identified specific spectral peaks that contribute to the molecular characteristics of the murine cancerous and non-cancerous tissues. ConclusionsConsequently, our integrated approach of machine learning and Raman spectroscopy presents a non-invasive, swift diagnostic tool for breast cancer, offering promising applications in intraoperative settings.
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- Award ID(s):
- 2046929
- PAR ID:
- 10568553
- Publisher / Repository:
- Springer
- Date Published:
- Journal Name:
- Biological Procedures Online
- Volume:
- 26
- Issue:
- 1
- ISSN:
- 1480-9222
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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