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Embedded ink writing (EIW) and direct ink writing (DIW) constitute the primary strategies for three-dimensional (3D) printing within the realm of material extrusion. These methods enable the rapid fabrication of complex 3D structures, utilizing either yield-stress support baths or self-supporting inks. Both these strategies have been extensively studied across a range of fields, including biomedical, soft robotics, and smart sensors, due to their outstanding print fidelity and compatibility with diverse ink materials. Particle additives capable of forming volume-filling 3D networks are frequently incorporated into polymer solvents. This integration is crucial for engineering the requisite microstructures essential for the formulation of successful support bath and ink materials. The interplay between the particle additives and polymer solvents is critical for achieving rheological tunability in various 3D printing strategies, yet this area has not been systematically reviewed. Therefore, in this critical review, we examined various mechanisms of particle–polymer interactions, the resulting microstructures, and their subsequent impact on mechanical and rheological properties. Overall, this work aims to serve as a foundational guideline for the design of next-generation materials in the field of extrusion additive manufacturing, specifically for EIW and DIW.
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High‐Speed Embedded Ink Writing of Anatomic‐Size Organ Constructs
Abstract Embedded ink writing (EIW) is an emerging 3D printing technique that fabricates complex 3D structures from various biomaterial inks but is limited to a printing speed of ∼10 mm s−1due to suboptimal rheological properties of particulate‐dominated yield‐stress fluids when used as liquid baths. In this work, a particle‐hydrogel interactive system to design advanced baths with enhanced yield stress and extended thixotropic response time for realizing high‐speed EIW is developed. In this system, the interactions between particle additive and three representative polymeric hydrogels enable the resulting nanocomposites to demonstrate different rheological behaviors. Accordingly, the interaction models for the nanocomposites are established, which are subsequently validated by macroscale rheological measurements and advanced microstructure characterization techniques. Filament formation mechanisms in the particle‐hydrogel interactive baths are comprehensively investigated at high printing speeds. To demonstrate the effectiveness of the proposed high‐speed EIW method, an anatomic‐size human kidney construct is successfully printed at 110 mm s−1, which only takes ∼4 h. This work breaks the printing speed barrier in current EIW and propels the maximum printing speed by at least 10 times, providing an efficient and promising solution for organ reconstruction in the future.
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- PAR ID:
- 10571339
- Publisher / Repository:
- Wiley
- Date Published:
- Journal Name:
- Advanced Science
- ISSN:
- 2198-3844
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
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Accepted Manuscript
- Journal Article:
- https://doi.org/10.1002/advs.202405980
