An official website of the United States government
In recent years, electronic packaging has evolved significantly to meet demands for higher performance, lower costs, and smaller designs. This shift has led to heterogeneous packaging, which integrates chips of varying stack heights and results in non-uniform heat flux and temperature distributions. These conditions pose substantial thermal management challenges, as they can create large temperature gradients, which increase thermal stress and potentially compromise chip reliability. This study explores single-phase liquid cooling for multi-chip modules (MCMs) through a comprehensive experimental and machine learning approach. It investigates the impact of chip spacing, height, fluid flow rate, fluid inlet location, and heat flux uniformity on chip temperature and the thermohydraulic performance of a commercial cold plate. Results show that increasing coolant flow from 1 LPM to 2 LPM decreased thermal resistance by 26 %, with heat losses remaining below 5 %. The left inlet configuration improved temperature uniformity compared to the right, though both yielded comparable thermal performance. Adjusting heater spacing impacted temperature distribution based on inlet position, and lowering one heater by 1 mm raised its temperatures by 15 ◦C due to increased thermal resistance from thermal interface material. A transient test demonstrated the cold plate’s quick response to power surges, in which there is only a 1 ◦C spike above steady state. Complementing these findings, an Artificial Neural Network (ANN) model was developed with optimized architecture specifically for the unique challenges of this study. The ANN model was rigorously validated using an independent dataset, achieving highly accurate temperature predictions (R2 = 0.99) within 2.5 % of experimental
more »
« less
Developing affordable and efficient heating devices for enhanced live cell imaging in confocal microscopy
Temperature control is crucial for live cell imaging, particularly in studies involving plant responses to high ambient temperatures and thermal stress. This study presents the design, development, and testing of two cost-effective heating devices tailored for confocal microscopy applications: an aluminum heat plate and a wireless mini-heater. The aluminum heat plate, engineered to integrate seamlessly with the standard 160 mm × 110 mm microscope stage, supports temperatures up to 36°C, suitable for studies in the range of non-stressful warm temperatures (e.g., 25-27°C forArabidopsis thaliana) and moderate heat stress (e.g., 30-36°C forA. thaliana). We also developed a wireless mini-heater that offers rapid, precise heating directly at the sample slide, with a temperature increase rate over 30 times faster than the heat plate. The wireless heater effectively maintained target temperatures up to 50°C, ideal for investigating severe heat stress and heat shock responses in plants. Both devices performed well in controlled studies, including the real-time analysis of heat shock protein accumulation and stress granule formation inA. thaliana. Our designs are effective and affordable, with total construction costs lower than $300. This accessibility makes them particularly valuable for small laboratories with limited funding. Future improvements could include enhanced heat uniformity, humidity control to mitigate evaporation, and more robust thermal management to minimize focus drift during extended imaging sessions. These modifications would further solidify the utility of our heating devices in live cell imaging, offering researchers reliable, budget-friendly tools for exploring plant thermal biology.
more »
« less
- PAR ID:
- 10574390
- Publisher / Repository:
- Frontiers Media
- Date Published:
- Journal Name:
- Frontiers in Plant Science
- Volume:
- 15
- ISSN:
- 1664-462X
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
More Like this
-
-
The demand for flexible microelectronics has increased significantly within the last decade. This study investigates the cooling performance of flexible pulsating heat pipes (PHPs) made from acrylic with a bend radius of ≈300 mm. The fabricated devices support two-phase, pulsating fluid flow inside the rectangular microchannels. Both water and ethanol are used as coolants, where local hot spots are generated by cobalt-alloy foil heaters inside the flexible PHPs. The PHP's dissipate the heat generated to the environment via copper condensers with controlled setpoint temperatures. Based on a heater surface area of ≈1.5 cm 2 and a condenser setpoint temperature of 25°C, the maximum heat flux observed for sustained and repeatable cooling with water and ethanol was 8 W /cm 2 . These heat fluxes correlate well with other PHP studies with similar heater power loads, channel geometries, and coolants.more » « less
-
Warming and nutrient limitation are stressors known to weaken the health of microalgae. In situations of stress, access to energy reserves can minimize physiological damage. Because of its widespread requirements in biochemical processes, iron is an important trace metal, especially for photosynthetic organisms. Lowered iron availability in oceans experiencing rising temperatures may contribute to the thermal sensitivity of reef‐building corals, which rely on mutualisms with dinoflagellates to survive. To test the influence of iron concentration on thermal sensitivity, the physiological responses of cultured symbiotic dinoflagellates (genusBreviolum; family Symbiodiniaceae) were evaluated when exposed to increasing temperatures (26 to 30°C) and iron concentrations ranging from replete (500 pM Fe’) to limiting (50 pM Fe’) under a diurnal light cycle with saturating radiance. Declines in photosynthetic efficiency at elevated temperatures indicated sensitivity to heat stress. Furthermore, five times the amount of iron was needed to reach exponential growth during heat stress (50 pM Fe′ at 26–28°C vs. 250 pM Fe′ at 30°C). In treatments where exponential growth was reached,Breviolum psygmophilumgrew faster thanB.minutum, possibly due to greater cellular contents of iron and other trace metals. The metal composition ofB.psygmophilumshifted only at the highest temperature (30°C), whereas changes inB.minutumwere observed at lower temperatures (28°C). The influence of iron availability in modulating each alga’s response to thermal stress suggests the importance of trace metals to the health of coral‐algal mutualisms. Ultimately, a greater ability to acquire scarce metals may improve the tolerance of corals to physiological stressors and contribute to the differences in performance associated with hosting one symbiont species over another.more » « less
-
The increasing prevalence of high-performance computing data centers necessitates the adoption of cutting-edge cooling technologies to ensure the safe and reliable operation of their powerful microprocessors. Two-phase cooling schemes are well-suited for high heat flux scenarios because of their high heat transfer coefficients and their ability to enhance chip temperature uniformity. In this study, we perform experimental characterization and deep learning driven optimization of a commercial two-phase cold plate. The initial working design of the cold plate comprises a fin height of 3mm, fin thickness of 0.1 mm, and a channel width of 0.1 mm.A dielectric coolant, Novec /HFE 7000, was impinged into microchannel fins through impinging jets. A copper block simulated an electronic chip with a surface area of 1˝ × 1˝. The experiment was conducted with three different coolant inlet temperatures of 25◦ C, 36◦ C, and 48◦ C with varying heat flux levels ranging from 7.5 to 73.5 W cm2. The effects of coolant inlet temperatures and flow rate on the thermo-hydraulic performance of the cold plate were explored. In two-phase flow, increasing coolant inlet temperature results in more nucleation sites and improved thermal performance consequently. Thermal resistance drops with flow rate in single-phase flow while it is not affected by flow rate in nucleate boiling region. An improvement in the design of the cold plate was carried out, with the goal of increasing the number of bubble sites and flow velocity at the root fins, by cutting the original fins and creating channels perpendicular to the original channels. Three design parameters, fin height, width of machined channels, and height of short fins preserved through machined channels, were defined. It was observed that widening the machined channels and cutting fins to some point can improve the thermal performance of the cold plate. However, removing fins excessively adversely affects the thermal performance of the cold plate because of loss of heat transfer surface area. Moreover, preserving the short fins through the machined channels decreases thermal resistance as they increase heat transfer surface area and nucleation sites. Furthermore, a deep learning-based compact model is demonstrated for the two-phase cold plate design in the specific range of geometry and flow conditions. The developed compact model is utilized to drive the single and multi-objective optimization to arrive at global optimal results.more » « less
-
Abstract Species interactions are expected to change in myriad ways as the frequency and magnitude of extreme temperature events increase with anthropogenic climate change.The relationships between endosymbionts, parasites and their hosts are particularly sensitive to thermal stress, which can have cascading effects on other trophic levels.We investigate the interactive effects of heat stress and parasitism on a terrestrial tritrophic system consisting of two host plants (one common, high‐quality plant and one novel, low‐quality plant), a caterpillar herbivore and a specialist parasitoid wasp.We used a fully factorial experiment to determine the bottom‐up effects of the novel host plant on both the caterpillars' life history traits and the wasps' survival, and the top‐down effects of parasitism and heat shock on caterpillar developmental outcomes and herbivory levels.Host plant identity interacted with thermal stress to affect wasp success, with wasps performing better on the low‐quality host plant under constant temperatures but worse under heat‐shock conditions.Surprisingly, caterpillars consumed less leaf material from the low‐quality host plant to reach the same final mass across developmental outcomes.In parasitized caterpillars, heat shock reduced parasitoid survival and increased both caterpillar final mass and development time on both host plants.These findings highlight the importance of studying community‐level responses to climate change from a holistic and integrative perspective and provide insight into potential substantial interactions between thermal stress and diet quality in plant–insect systems. Read the freePlain Language Summaryfor this article on the Journal blog.more » « less
- Free Publicly Accessible Full Text
-
Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.3389/fpls.2024.1499831
