An official website of the United States government
Abstract Natural organisms have evolved a series of versatile functional biomaterials and structures to cope with survival crises in their living environment, exhibiting outstanding properties such as superhydrophobicity, anisotropy, and mechanical reinforcement, which have provided abundant inspiration for the design and fabrication of next‐generation multi‐functional devices. However, the lack of available materials and limitations of traditional manufacturing methods for complex multiscale structures have hindered the progress in bio‐inspired manufacturing of functional structures. As a revolutionary emerging manufacturing technology, additive manufacturing (i.e., 3D printing) offers high design flexibility and manufacturing freedom, providing the potential for the fabrication of intricate, multiscale, hierarchical, and multi‐material structures. Herein, a comprehensive review of current 3D printing of surface/interface structures, covering the applied materials, designs, and functional applications is provided. Several bio‐inspired surface structures that have been created using 3D printing technology are highlighted and categorized based on their specific properties and applications, some properties can be applied to multiple applications. The optimized designs of these 3D‐printed bio‐inspired surfaces offer a promising prospect of low‐cost, high efficiency, and excellent performance. Finally, challenges and opportunities in field of fabricating functional surface/interface with more versatile functional material, refined structural design, and better cost‐effective are discussed.
more »
« less
3D‐Printed Polymeric Biomaterials for Health Applications
Abstract 3D printing, also known as additive manufacturing, holds immense potential for rapid prototyping and customized production of functional health‐related devices. With advancements in polymer chemistry and biomedical engineering, polymeric biomaterials have become integral to 3D‐printed biomedical applications. However, there still exists a bottleneck in the compatibility of polymeric biomaterials with different 3D printing methods, as well as intrinsic challenges such as limited printing resolution and rates. Therefore, this review aims to introduce the current state‐of‐the‐art in 3D‐printed functional polymeric health‐related devices. It begins with an overview of the landscape of 3D printing techniques, followed by an examination of commonly used polymeric biomaterials. Subsequently, examples of 3D‐printed biomedical devices are provided and classified into categories such as biosensors, bioactuators, soft robotics, energy storage systems, self‐powered devices, and data science in bioplotting. The emphasis is on exploring the current capabilities of 3D printing in manufacturing polymeric biomaterials into desired geometries that facilitate device functionality and studying the reasons for material choice. Finally, an outlook with challenges and possible improvements in the near future is presented, projecting the contribution of general 3D printing and polymeric biomaterials in the field of healthcare.
more »
« less
- PAR ID:
- 10575782
- Author(s) / Creator(s):
- ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; more »
- Publisher / Repository:
- Wiley
- Date Published:
- Journal Name:
- Advanced Healthcare Materials
- Volume:
- 14
- Issue:
- 1
- ISSN:
- 2192-2640
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
More Like this
-
-
Abstract Bioprinting is an additive manufacturing technique that combines living cells, biomaterials, and biological molecules to develop biologically functional constructs. Three-dimensional (3D) bioprinting is commonly used as anin vitromodeling system and is a more accurate representation ofin vivoconditions in comparison to two-dimensional cell culture. Although 3D bioprinting has been utilized in various tissue engineering and clinical applications, it only takes into consideration the initial state of the printed scaffold or object. Four-dimensional (4D) bioprinting has emerged in recent years to incorporate the additional dimension of time within the printed 3D scaffolds. During the 4D bioprinting process, an external stimulus is exposed to the printed construct, which ultimately changes its shape or functionality. By studying how the structures and the embedded cells respond to various stimuli, researchers can gain a deeper understanding of the functionality of native tissues. This review paper will focus on the biomaterial breakthroughs in the newly advancing field of 4D bioprinting and their applications in tissue engineering and regeneration. In addition, the use of smart biomaterials and 4D printing mechanisms for tissue engineering applications is discussed to demonstrate potential insights for novel 4D bioprinting applications. To address the current challenges with this technology, we will conclude with future perspectives involving the incorporation of biological scaffolds and self-assembling nanomaterials in bioprinted tissue constructs.more » « less
-
Abstract Hydrogels with particulates, including proteins, drugs, nanoparticles, and cells, enable the development of new and innovative biomaterials. Precise control of the spatial distribution of these particulates is crucial to produce advanced biomaterials. Thus, there is a high demand for manufacturing methods for particle-laden hydrogels. In this context, 3D printing of hydrogels is emerging as a promising method to create numerous innovative biomaterials. Among the 3D printing methods, inkjet printing, so-called drop-on-demand (DOD) printing, stands out for its ability to construct biomaterials with superior spatial resolutions. However, its printing processes are still designed by trial and error due to a limited understanding of the ink behavior during the printing processes. This review discusses the current understanding of transport processes and hydrogel behaviors during inkjet printing for particulate-laden hydrogels. Specifically, we review the transport processes of water and particulates within hydrogel during ink formulation, jetting, and curing. Additionally, we examine current inkjet printing applications in fabricating engineered tissues, drug delivery devices, and advanced bioelectronics components. Finally, the challenges and opportunities for next-generation inkjet printing are also discussed. Graphical Abstractmore » « less
-
null (Ed.)Abstract Following the success of 3D printing with synthetic polymers like ABS, FLA, Nylon, etc., scientists and researchers have been putting efforts into fabricating bio-compatible materials. It has not only broadened the field of bioengineering and manufacturing but also regenerative medicine. Unlike the traditional 3D printing process, additive bio-manufacturing, also known as 3D bio-printing has a lot of challenges like cell survivability and proliferation, and the mechanical properties of the biomaterials which involve printability and the ability to hold its structural integrity. Proper design of experiments with extensive rheological investigation can help identify useful mechanical property ranges which are directly related to the geometric fidelity of 3D bio-printed scaffolds. Therefore, to investigate the printability of a low viscosity Alginate-Carboxymethyl Cellulose (CMC), multiple concentrations of the mixture were tested maintaining a 8% (w/v) solid content. A set of rheological tests such as the Steady Rate Sweep Test, Three Point Thixotropic Test (3ITT), and Amplitude test were performed. The outcome of those tests showed that the rheological properties can be controlled with the percentage of CMC in the mixtures. The fabricated filaments and scaffolds in the 5 combinations of CMC percentages were analyzed for flowability and shape fidelity. The rheological results and the printability and shape fidelity results were analyzed.more » « less
-
In recent years, inkjet printing has become a popular form for creating sensors and antennas. These devices are fabricated using different materials with inkjet printing using various (conductive, oxide, biological) inks on predominantly flexible substrate. This form of fabrication has attracted much attention for a variety of reasons such as relatively cheap cost of manufacturing and materials, as well as the ease of use and high customization. These devices also provide a lighter frame and added flexibility allowing them to be incorporated as devices on non-planar surfaces. It is also possible for inkjet printing to be used as a sustainable manufacturing method, providing a method of reducing electronic waste. In this article, several topics related to inkjet printing are covered. These topics include a general overview of the fabrication process of inkjet devices through an inkjet printer, recent applications of inkjet-printed sensors, applications of inkjet-printed antennae, challenges in inkjet printing, and an outlook on the inkjet printing. In the fabrication section, the different materials and printing process are explored. Topics covered in the application section include gas sensors, biomedical sensors, pressure sensors, temperature sensors, glucose sensors, and more. In the inkjet antennas portion of the article, RFID tagging and 5G applications are highlighted. The main challenges covered are specific to fabrication that are being currently addressed.more » « less
- Free Publicly Accessible Full Text
-
Accepted Manuscript
- Journal Article:
- https://doi.org/10.1002/adhm.202402571
