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Abstract Study ObjectivesTo investigate associations between social jet lag and the developing adolescent brain. MethodsN = 3507 youth (median (IQR) age = 12.0 (1.1) years; 50.9% females) from the Adolescent Brain Cognitive Development cohort were studied. Social jet lag (adjusted for sleep debt [SJLSC] vs. nonadjusted [SJL]), topological properties and intrinsic dynamics of resting-state networks, and morphometric brain characteristics were analyzed. ResultsOver 35% of participants had SJLSC ≥ 2.0 h. Boys, Hispanic and Black non-Hispanic youth, and/or those at later pubertal stages had longer SJLSC (β = 0.06–0.68, CI = [0.02, 0.83], p ≤ .02), which was also associated with higher Body Mass Index (BMI) (β = 0.13, CI = [0.08, 0.18], p < .01). SJLSC and SJL were associated with lower strength of thalamic connections (β = −0.22, CI = [−0.39, −0.05], p = .03). Longer SJLSC was also associated with lower topological resilience and lower connectivity of the salience network (β = −0.04, CI = [−0.08, −0.01], p = .04), and lower thickness and/or volume of structures overlapping with this and other networks supporting emotional and reward processing and social function (β =−0.08 to −0.05, CI = [−0.12, −0.01], p < .05). Longer SJL was associated with lower connectivity and efficiency of the dorsal attention network (β = −0.05, CI = [−0.10, −0.01], p < .05). Finally, SJLSC and SJL were associated with alterations in spontaneously coordinated brain activity and lower information transfer between regions supporting sensorimotor integration, social function, and emotion regulation (β = −0.07 to −0.05, CI = [−0.12, −0.01], p < .04). ConclusionsMisaligned sleep is associated with widespread alterations in adolescent brain structures, circuit organization, and dynamics of regions that play critical roles in cognitive (including social) function, and emotion and reward regulation.
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Dynamic fluctuations of intrinsic brain activity are associated with consistent topological patterns in puberty and are biomarkers of neural maturation
Abstract Intrinsic brain dynamics play a fundamental role in cognitive function, but their development is incompletely understood. We investigated pubertal changes in temporal fluctuations of intrinsic network topologies (focusing on the strongest connections and coordination patterns) and signals, in an early longitudinal sample from the Adolescent Brain Cognitive Development (ABCD) study, with resting-state fMRI (n = 4,099 at baseline; n = 3,376 at follow-up [median age = 10.0 (1.1) and 12.0 (1.1) years; n = 2,116 with both assessments]). Reproducible, inverse associations between low-frequency signal and topological fluctuations were estimated (p < 0.05, β = −0.20 to −0.02, 95% confidence interval (CI) = [−0.23, −0.001]). Signal (but not topological) fluctuations increased in somatomotor and prefrontal areas with pubertal stage (p < 0.03, β = 0.06–0.07, 95% CI = [0.03, 0.11]), but decreased in orbitofrontal, insular, and cingulate cortices, as well as cerebellum, hippocampus, amygdala, and thalamus (p < 0.05, β = −0.09 to −0.03, 95% CI = [−0.15, −0.001]). Higher temporal signal and topological variability in spatially distributed regions were estimated in girls. In racial/ethnic minorities, several associations between signal and topological fluctuations were in the opposite direction of those in the entire sample, suggesting potential racial differences. Our findings indicate that during puberty, intrinsic signal dynamics change significantly in developed and developing brain regions, but their strongest coordination patterns may already be sufficiently developed and remain temporally consistent.
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- PAR ID:
- 10578991
- Publisher / Repository:
- DOI PREFIX: 10.1162
- Date Published:
- Journal Name:
- Network Neuroscience
- Volume:
- 9
- Issue:
- 3
- ISSN:
- 2472-1751
- Format(s):
- Medium: X Size: p. 1039-1064
- Size(s):
- p. 1039-1064
- Sponsoring Org:
- National Science Foundation
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