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Title: Ferric Chloride Promoted Glycosidation of Alkyl Thioglycosides
Reported herein is a new reaction for glycosylation with thioglycosides in the presence of iron(III) chloride. Previously, FeCl3 was used for the activation of thioglycosides as a Lewis acid co-promoter paired with NIS. In the reported process, although 5.0 equiv of FeCl3 are needed to activate thioglycosides most efficiently, no additives were used, and the reactions with reactive glycosyl donors smoothly proceeded to completion in 1 h at 0 °C. This work showcases a new direction in developing glycosylation methods using greener and earth-abundant activators.  more » « less
Award ID(s):
2350461
PAR ID:
10582919
Author(s) / Creator(s):
; ; ;
Publisher / Repository:
MDPI
Date Published:
Journal Name:
Molecules
Volume:
29
Issue:
20
ISSN:
1420-3049
Page Range / eLocation ID:
4845
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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