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1. In crystallo homolytic cleavage of a terminal lanthanum( iii )–methyl bond by Cu Kα X-radiation forms a La( ii ) complex

   https://doi.org/10.1039/D5CC04945H  

   Stennett, Cary R; Luevano, Makayla R; Ziller, Joseph W; Evans, William J (January 2026, Chemical Communications)

   A new La(ii) synthesis involves SCXRD experiments on the La(iii) methyl complex La(SAr^iPr6)₂CH₃, Ar^iPr6= C₆H₃-2,6-(C₆H₂-2,4,6-ⁱPr₃)₂, with Cu Kα X-rays that results in homolytic La-CH₃cleavage and formation of the La(ii) complex La(SAr^iPr6)₂. 

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2. Cardiac MR Fingerprinting at 0.55T Using a Deep Image Prior for Joint T₁ , T₂ , and M₀ Mapping

   https://doi.org/10.1002/jmri.70239  

   Liu, Zhongnan; Liu, Zexuan; Rashid, Imran; Galizia, Mauricio Stanzione; Scoma, Christopher; Truesdell, William; Agarwal, Prachi; Seiberlich, Nicole; Shen, Liyue; Hamilton, Jesse (January 2026, Journal of Magnetic Resonance Imaging)

   ABSTRACT Background0.55T systems offer unique advantages and may support expanded access to cardiac MRI. PurposeTo assess the feasibility of 0.55T cardiac MR Fingerprinting (MRF), leveraging a deep image prior reconstruction to mitigate noise. Study TypePhantom and prospective in vivo assessment. PopulationISMRM/NIST MRI system phantom and 18 healthy subjects (11 female; ages 28 ± 8 years). Field Strength and SequencesMRF, modified Look‐Locker inversion recovery (MOLLI), and T₂‐prepared balanced steady state free precession (T₂‐bSSFP) at 0.55T. AssessmentMRF T₁and T₂maps were reconstructed using (1) a low‐rank technique with sparse and locally low‐rank regularization (SLLR‐MRF) and (2) a deep image prior (DIP‐MRF). Accuracy and precision of MRF and conventional sequences were evaluated in a phantom. In vivo performance of MRF was evaluated in the 18 healthy subjects, with 7 subjects also undergoing conventional mapping. Myocardial T₁and T₂values were compared among methods and image quality scored by three readers (2, 3, and 4 years of experience) on a 5‐point scale. Statistical TestsLinear regression, Bland–Altman, intraclass correlation coefficient, and one‐way ANOVA withp < 0.05 considered significant. ResultsMean measurements in the left ventricular septum were 671 ± 31 ms (MOLLI), 761 ± 147 ms (SLLR‐MRF), and 686 ± 39 ms (DIP‐MRF) for T₁, and 63.5 ± 5.7 ms (T₂‐bSSFP), 47.5 ± 12.7 ms (SLLR‐MRF), and 45.2 ± 4.5 ms (DIP‐MRF) for T₂. Compared to conventional mapping, DIP‐MRF exhibited significantly lower T₂but no differences in T₁(p > 0.99). Standard deviations within the myocardium were significantly lower with DIP‐MRF compared to SLLR‐MRF (39 vs. 147 ms for T₁and 4.5 vs. 12.7 ms for T₂). Overall image quality ratings were significantly lower for SLLR‐MRF (T₁: 2.3, T₂: 2.9), which were significantly lower compared to conventional mapping methods (T₁: 3.4, T₂: 3.9), and DIP‐MRF (T₁: 3.8, T₂: 4.1) received higher scores. Data ConclusionThis study demonstrated the feasibility of cardiac MRF on a commercial 0.55T system, enabled by a deep image prior reconstruction for denoising. Evidence Level2. Stage of Technical Efficacy1. 

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3. ND70 Series Basaltic Glass Reference Materials for Volatile Element ( H₂O , CO₂ , S, Cl, F) Measurement and the C Ionisation Efficiency Suppression Effect of Water in Silicate Glasses in SIMS

   https://doi.org/10.1111/ggr.12572  

   Moussallam, Yves; Towbin, William Henry; Plank, Terry; Bureau, Hélène; Khodja, Hicham; Guan, Yunbin; Ma, Chi; Baker, Michael B; Stolper, Edward M; Naab, Fabian U; et al (July 2024, Geostandards and Geoanalytical Research)

   We present a new set of reference materials, the ND70‐series, forin situmeasurement of volatile elements (H₂O, CO₂, S, Cl, F) in silicate glass of basaltic composition. The materials were synthesised in piston cylinders at pressures of 1 to 1.5 GPa under volatile‐undersaturated conditions. They span mass fractions from 0 to 6%m/mH₂O, from 0 to 1.6%m/mCO₂and from 0 to 1%m/mS, Cl and F. The materials were characterised by elastic recoil detection analysis for H₂O, by nuclear reaction analysis for CO₂, by elemental analyser for CO₂, by Fourier transform infrared spectroscopy for H₂O and CO₂, by secondary ion mass spectrometry for H₂O, CO₂, S, Cl and F, and by electron probe microanalysis for CO₂, S, Cl and major elements. Comparison between expected and measured volatile amounts across techniques and institutions is excellent. It was found however that SIMS measurements of CO₂mass fractions using either Cs⁺or O⁻primary beams are strongly affected by the glass H₂O content. Reference materials have been made available to users at ion probe facilities in the US, Europe and Japan. Remaining reference materials are preserved at the Smithsonian National Museum of Natural History where they are freely available on loan to any researcher. 

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4. Exploring sulfur donor atom coordination chemistry with La( ii ), Nd( ii ), and Tm( ii ) using a terphenylthiolate ligand

   https://doi.org/10.1039/d4cc01037j  

   Gilbert-Bass, Kito; Stennett, Cary R.; Grotjahn, Robin; Ziller, Joseph W.; Furche, Filipp; Evans, William J. (April 2024, Chemical Communications)

   To expand the range of donor atoms known to stabilize 4fⁿ5d¹Ln(ii) ions beyond C, N, and O first row main group donor atoms, the Ln(iii) terphenylthiolate iodides, Ln^III(SAr^iPr6)₂I (Ar^iPr6= C₆H₃-2,6-(C₆H₂-2,4,6-ⁱPr₃)₂, Ln = La, Nd) were reduced to Ln^II(SAr^iPr6)₂complexes. 

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5. 24R ,25( OH ) ₂D₃ regulates tumorigenesis in estrogen sensitive laryngeal cancer cells via membrane‐associated receptor complexes in ER + and ER− cells

   https://doi.org/10.1002/ijc.70141  

   Dennis, Cydney D; Cohen, D Joshua; Debnath, Kusal; Schwartz, Nofrat; Lodato, Brock P; Dillon, Jonathan T; Batool, Tillat; Halquist, Matthew S; Ghosh, Preetam; Schwartz, Zvi; et al (September 2025, International Journal of Cancer)

   Abstract This study examined the effects of 24R,25‐dihydroxyvitamin D₃(24R,25(OH)₂D₃) in estrogen‐responsive laryngeal cancer tumorigenesis in vivo, the mechanisms involved, and whether the ability of the tumor cells to produce 24R,25(OH)₂D₃locally is estrogen‐dependent. Estrogen receptor alpha‐66 positive (ER+) UM‐SCC‐12 cells and ER− UM‐SCC‐11A cells responded differently to 24R,25(OH)₂D₃in vivo; 24R,25(OH)₂D₃enhanced tumorigenesis in ER+ tumors but inhibited tumorigenesis in ER− tumors. Treatment with 17β‐estradiol (E₂) for 24 h reduced levels of CYP24A1 protein but increased 24R,25(OH)₂D₃production in ER+ cells; treatment with E₂for 9 min reduced CYP24A1 at 24 h and reduced 24R,25(OH)₂D₃production in ER− cells. These findings suggest the involvement of E₂receptor(s) in addition to ERα66. To investigate if 24R,25(OH)₂D₃can act locally, ER+ and ER− cells were treated with 24R,25(OH)₂D₃after inhibiting putative 24R,25(OH)₂D₃receptors, and the cells were assessed for effects on DNA synthesis (proliferation) and p53 production (apoptosis). Specific inhibitors were used to assess downstream secondary messenger signaling pathways and requirements for palmitoylation and caveolae in both cell lines. The results show that 24R,25(OH)₂D₃binds to a complex of receptors, including TLCD3B2, VDR, and protein disulfide‐isomerase A3 (PDIA3) in ER+ UM‐SCC‐12 cells. The mechanism requires palmitoylation, and PLD, PI3K, and LPAR are involved. The anti‐tumorigenic effects of 24R,25(OH)₂D₃in ER− UM‐SCC‐11A cells involve a membrane‐receptor complex consisting of VDR, PDIA3, and ROR2 within caveolae to activate a yet‐to‐be‐elucidated downstream signaling cascade. This work demonstrates a driving mechanism for the therapeutic agent 24R,25(OH)₂D₃that may be used for laryngeal cancer patients. 

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