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Title: Irreversibility in bacterial regulatory networks
Irreversibility, in which a transient perturbation leaves a system in a new state, is an emergent property in systems of interacting entities. This property has well-established implications in statistical physics but remains underexplored in biological networks, especially for bacteria and other prokaryotes whose regulation of gene expression occurs predominantly at the transcriptional level. Focusing on the reconstructed regulatory network ofEscherichia coli, we examine network responses to transient single-gene perturbations. We predict irreversibility in numerous cases and find that the incidence of irreversibility increases with the proximity of the perturbed gene to positive circuits in the network. Comparison with experimental data suggests a connection between the predicted irreversibility to transient perturbations and the evolutionary response to permanent perturbations.  more » « less
Award ID(s):
2206974
PAR ID:
10592177
Author(s) / Creator(s):
; ; ;
Publisher / Repository:
Science Advances
Date Published:
Journal Name:
Science Advances
Volume:
10
Issue:
35
ISSN:
2375-2548
Page Range / eLocation ID:
eado3232
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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