skip to main content
US FlagAn official website of the United States government
dot gov icon
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
https lock icon
Secure .gov websites use HTTPS
A lock ( lock ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Explore Research Products in the PAR
It may take a few hours for recently added research products to appear in PAR search results.


  • NSF Public Access
  • Search Results
  • A Case of One Step Forward and Two Steps Back? An Examination of Herbicide-Resistant Weed Management Using a Simple Agroecosystem Dynamics Model

This content will become publicly available on December 1, 2025

Title: A Case of One Step Forward and Two Steps Back? An Examination of Herbicide-Resistant Weed Management Using a Simple Agroecosystem Dynamics Model
Global herbicide-resistant weed populations continue rising due to selection pressures exerted by herbicides. Despite this, herbicides continue to be farmers’ preferred weed-control method due to cost and efficiency relative to physical or biological methods. However, weeds developing resistance to herbicides not only challenges crop production but also threatens ecosystem services by disrupting biodiversity, reducing soil health, and impacting water quality. Our objective was to develop a simulation model that captures the feedback between weed population dynamics, agricultural management, profitability, and farmer decision-making processes that interact in unique ways to reinforce herbicide resistance in weeds. After calibration to observed data and evaluation by subject matter experts, we tested alternative agronomic, mechanical, or intensive management strategies to evaluate their impact on weed population dynamics. Results indicated that standalone practices enhanced farm profitability in the short term but lead to substantial adverse ecological outcomes in the long term, indicated by elevated herbicide resistance (e.g., harm to non-target species, disrupting natural ecosystem functions). The most management-intensive test yielded the greatest weed control and farm profit, albeit with elevated residual resistant seed bank levels. We discuss these findings in both developed and developing-nation contexts. Future work requires greater connectivity of farm management and genetic-resistance models that currently remain disconnected mechanistically.  more » « less
Award ID(s):
1914745
PAR ID:
10596066
Author(s) / Creator(s):
; ; ; ; ; ;
Publisher / Repository:
MDPI
Date Published:
Journal Name:
Systems
Volume:
12
Issue:
12
ISSN:
2079-8954
Page Range / eLocation ID:
587
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
More Like this
  1. ; ; ; (, Agronomy Journal)
    null (Ed.)
    With over 65% of agronomic crops under no-till in Pennsylvania, herbicides are relied on for weed management. To lessen the environmental impact and selection pressure for herbicide resistance, we conducted a nine-year experiment to test herbicide reduction practices in a dairy crop rotation at Rock Springs, PA. The rotation included soybean (Glycine max L.) – corn (Zea mays L.) - 3-year alfalfa (Medicago sativa L.) - canola (Brassica napus L.). The following practices were used to reduce herbicide inputs: i. banding residual herbicides over corn and soybean rows and using high-residue inter-row cultivation; ii. seeding a small grain companion crop with alfalfa; iii. plowing once in six years to terminate the perennial forage. These practices were compared with standard herbicide-based weed management (SH) in continuous no-till. We hypothesized: i. There would be more weed biomass in the reduced herbicide treatment (RH), ii. leading to more weeds in RH over time, but iii. the added weed pressure would not affect yield iv. or differences in net return. We sampled weed biomass in soybean, corn, and the first two forage years. In corn and soybean, weed biomass was often greater in RH than SH and increased over the years in the RH treatments. In the forage, weed biomass did not always differ between treatments. Yield and differences in net return were similar in most crops and years. Results suggest that weed management with reduced herbicide inputs supplemented with an integrated approach can be effective but may lead to more weeds over time. 
    more » « less
  2. ; ; (, American Journal of Agricultural Economics)
    null (Ed.)
    Conservation tillage in American soybean production has become increasingly common, improving soil health while reducing soil erosion and fuel consumption. This trend has been reinforced by the widespread adoption of glyphosate-based weed control systems. Many weed species have since evolved to resist glyphosate, reducing its effectiveness. We provide evidence that the spread of glyphosate-resistant weeds is responsible for significant reductions in the use of conservation tillage in soybean production. We estimate reduced-form and structural probit models of tillage choice, using a large panel of field-level soybean management decisions from across the United States spanning 1998-2016. We find that the first emergence of glyphosate-resistant weed species has little initial effect on tillage practices, though by the time that eight glyphosate-resistant weed species are identified, conservation tillage and no-till use fall by 3.9 percentage points and 7.6 percentage points, respectively. We further find that when ten glyphosate-resistant species are present, the predicted adoption rate of non-glyphosate herbicides rises 50 percentage points, and that the availability of non-glyphosate herbicides facilitates continued use of conservation tillage as glyphosate-resistant weeds proliferate. Using a simple benefits transfer model, we conservatively estimate that between 2008 and 2016 farmers' tillage responses to the spread of glyphosate-resistant weeds have caused water quality and climate damages via fuel emissions valued at nearly $245 million. This value does not account for climate damages due to carbon released during soil disruptions and is likely to grow as glyphosate resistance becomes more widespread and more farmers turn to tillage for supplemental weed control. 
    more » « less
  3. ; (, Pest Management Science)
    Abstract Weed control has relied on the use of organic and inorganic molecules that interfere with druggable targets, especially enzymes, for almost a century. This approach, although effective, has resulted in multiple cases of herbicide resistance. Furthermore, the rate of discovery of new druggable targets that are selective and with favorable environmental profiles has slowed down, highlighting the need for innovative control tools. The arrival of the biotechnology and genomics era gave hope to many that all sorts of new control tools would be developed. However, the reality is that most efforts have been limited to the development of transgenic crops with resistance to a few existing herbicides, which in fact is just another form of selectivity. Proteolysis‐targeting chimera (PROTAC) is a new technology developed to treat human diseases but that has potential for multiple applications in agriculture. This technology uses a small bait molecule linked to an E3 ligand. The 3‐dimensional structure of the bait favors physical interaction with a binding site in the target protein in a manner that allows E3 recruitment, ubiquitination and then proteasome‐mediated degradation. This system makes it possible to circumvent the need to find druggable targets because it can degrade structural proteins, transporters, transcription factors, and enzymes without the need to interact with the active site. PROTAC can help control herbicide‐resistant weeds as well as expand the number of biochemical targets that can be used for weed control. In the present article, we provide an overview of how PROTAC works and describe the possible applications for weed control as well as the challenges that this technology might face during development and implementation for field uses. © 2023 The Authors.Pest Management Sciencepublished by John Wiley & Sons Ltd on behalf of Society of Chemical Industry. 
    more » « less
  4. ; ; ; (, Molecular Ecology)
    ABSTRACT Herbicide resistance in agricultural weeds has become one of the greatest challenges for sustainable crop production. The repeated evolution of herbicide resistance provides an excellent opportunity to study the genetic and physiological basis of the resistance phenotype and the evolutionary responses to human‐mediated selection pressures.Lolium multiflorumis a ubiquitous weed that has evolved herbicide resistance repeatedly around the world in various cropping systems. We assembled and annotated a chromosome‐scale genome forL. multiflorumand elucidated the genetic architecture of paraquat resistance by performing quantitative trait locus analysis, genome‐wide association studies, genetic divergence analysis and transcriptome analyses from paraquat‐resistant and ‐susceptibleL. multiflorumplants. We identified two regions on chromosome 5 that were associated with paraquat resistance. These regions both showed evidence for positive selection among the resistant populations we sampled, but the effects of this selection on the genome differed, implying a complex evolutionary history. In addition, these regions contained candidate genes that encoded cellular transport functions, including a novel multidrug and toxin extrusion (MATE) protein and a cation transporter previously shown to interact with polyamines. Given thatL. multiflorumis a weed and a cultivated crop species, the genomic resources generated will prove valuable to a wide spectrum of the plant science community. Our work contributes to a growing body of knowledge on the underlying evolutionary and ecological dynamics of rapid adaptation to strong anthropogenic selection pressure that could help initiate efforts to improve weed management practices in the long term for a more sustainable agriculture. 
    more » « less
  5. ; ; (, Communications Biology)
    Abstract Weedy rice is a close relative of cultivated rice that devastates rice productivity worldwide. In the southern United States, two distinct strains have been historically predominant, but the 21stcentury introduction of hybrid rice and herbicide resistant rice technologies has dramatically altered the weedy rice selective landscape. Here, we use whole-genome sequences of 48 contemporary weedy rice accessions to investigate the genomic consequences of crop-weed hybridization and selection for herbicide resistance. We find that population dynamics have shifted such that most contemporary weeds are now crop-weed hybrid derivatives, and that their genomes have subsequently evolved to be more like their weedy ancestors. Haplotype analysis reveals extensive adaptive introgression of cultivated alleles at the resistance geneALS, but also uncovers evidence for convergent molecular evolution in accessions with no signs of hybrid origin. The results of this study suggest a new era of weedy rice evolution in the United States. 
    more » « less
  • Citation Formats
  • MLA
  • APA
  • Chicago
  • BibTeX
  • Save / Share this Record
  • Send to Email