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1. Effects of Developmental Hypoxia on the Vertebrate Cardiovascular System

   https://doi.org/10.1152/physiol.00022.2022  

   Galli, Gina L.; Lock, Mitchell C.; Smith, Kerri L.; Giussani, Dino A.; Crossley, Dane A. (March 2023, Physiology)

   Developmental hypoxia has profound and persistent effects on the vertebrate cardiovascular system, but the nature, magnitude, and long-term outcome of the hypoxic consequences are species specific. Here we aim to identify common and novel cardiovascular responses among vertebrates that encounter developmental hypoxia, and we discuss the possible medical and ecological implications. 

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2. Fish Ear Stones Track Hypoxia Exposure

   https://doi.org/10.1002/bes2.1889  

   Steube, Tyler R.; Altenritter, Matthew E.; Walther, Benjamin D. (July 2021, The Bulletin of the Ecological Society of America)

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3. Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia

   https://doi.org/10.3389/fphys.2020.00886  

   Tift, Michael S.; Alves de Souza, Rodrigo W.; Weber, Janick; Heinrich, Erica C.; Villafuerte, Francisco C.; Malhotra, Atul; Otterbein, Leo E.; Simonson, Tatum S. (July 2020, Frontiers in Physiology)
4. Modeling the Impact of Abdominal Pressure on Hypoxia in Laboratory Swine

   https://doi.org/10.1115/1.4063478  

   KadkhodaeiElyaderani, Behzad; Leibowitz, Joshua L.; Moon, Yejin; Stachnik, Stephen; Awad, Morcos; Sarkar, Grace M.; Shaw, Anna E.; Stewart, Shelby; Culligan, Melissa; Friedberg, Joseph S.; et al (April 2023, ASME Letters in Dynamic Systems and Control)

   Abstract This paper presents an experimentally parameterized model of the dynamics of oxygen transport in a laboratory animal that simultaneously experiences: (i) a reduction in inspired oxygen plus (ii) an increase in intra-abdominal pressure. The goal is to model the potential impact of elevated intra-abdominal pressure on oxygen transport dynamics. The model contains three compartments, namely, the animal’s lungs, lower body vasculature, and upper body vasculature. The model assumes that intra-abdominal pressure affects the split of cardiac output among the two vasculature compartments and that aerobic metabolism in each compartment diminishes with severe hypoxia. Fitting this model to a laboratory experiment on an adult male Yorkshire swine using a regularized nonlinear least-squares approach furnishes both physiologically plausible parameter values plus a reasonable quality of fit. 

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5. Independent losses of the Hypoxia-Inducible Factor (HIF) Pathway within Crustacea

   Graham, Allie M; Barreto, Felipe S (January 2020, Molecular biology and evolution)

   Metazoans respond to hypoxic stress via the Hypoxia Inducible Factor (HIF) pathway, a mechanism thought to be extremely conserved due to its importance in monitoring cellular oxygen levels and regulating responses to hypoxia. However, recent work revealed that key members of the HIF pathway have been lost in specific lineages (a tardigrade and a copepod), suggesting this pathway is not as widespread in animals as previously assumed. Using genomic and transcriptomic data from 70 different species across 12 major crustacean groups, we assessed the degree to which the gene HIFα, the master regulator of the HIF pathway, was conserved. Mining of protein domains, followed by phylogenetic analyses of gene families, uncovered group-level losses of HIFα, including one across three orders within Cirripedia, and in three orders within Copepoda. For these groups, additional assessment showed losses of HIF repression machinery (EGLN, VHL). These results suggest the existence of alternative mechanisms for cellular response to low oxygen, and highlight these taxa as models useful for probing these evolutionary outcomes. 

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