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Title: Modeling the Impact of Abdominal Pressure on Hypoxia in Laboratory Swine
Abstract This paper presents an experimentally parameterized model of the dynamics of oxygen transport in a laboratory animal that simultaneously experiences: (i) a reduction in inspired oxygen plus (ii) an increase in intra-abdominal pressure. The goal is to model the potential impact of elevated intra-abdominal pressure on oxygen transport dynamics. The model contains three compartments, namely, the animal’s lungs, lower body vasculature, and upper body vasculature. The model assumes that intra-abdominal pressure affects the split of cardiac output among the two vasculature compartments and that aerobic metabolism in each compartment diminishes with severe hypoxia. Fitting this model to a laboratory experiment on an adult male Yorkshire swine using a regularized nonlinear least-squares approach furnishes both physiologically plausible parameter values plus a reasonable quality of fit.  more » « less
Award ID(s):
2121110 2227939
PAR ID:
10495155
Author(s) / Creator(s):
; ; ; ; ; ; ; ; ; ; ;
Publisher / Repository:
ASME L-DSC
Date Published:
Journal Name:
ASME Letters in Dynamic Systems and Control
Volume:
3
Issue:
2
ISSN:
2689-6117
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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