More Like this

1. Effect of elastic modulus of tumour and non-tumour cells on vibration-induced behaviours

   https://doi.org/10.1038/s41598-025-97837-z  

   Ku, BonHeon; Liu, Jing; Na, Sungsoo; Yokota, Hiroki; Hong, Chinsuk; Lim, HeeChang (December 2025, Scientific Reports)
2. Learning-accelerated discovery of immune-tumour interactions

   https://doi.org/10.1039/c9me00036d  

   Ozik, Jonathan; Collier, Nicholson; Heiland, Randy; An, Gary; Macklin, Paul (August 2019, Molecular Systems Design & Engineering)

   We present an integrated framework for enabling dynamic exploration of design spaces for cancer immunotherapies with detailed dynamical simulation models on high-performance computing resources. Our framework combines PhysiCell, an open source agent-based simulation platform for cancer and other multicellular systems, and EMEWS, an open source platform for extreme-scale model exploration. We build an agent-based model of immunosurveillance against heterogeneous tumours, which includes spatial dynamics of stochastic tumour–immune contact interactions. We implement active learning and genetic algorithms using high-performance computing workflows to adaptively sample the model parameter space and iteratively discover optimal cancer regression regions within biological and clinical constraints. 

   more » « less
3. Cooperative phagocytosis of solid tumours by macrophages triggers durable anti-tumour responses

   https://doi.org/10.1038/s41551-023-01031-3  

   Dooling, Lawrence J.; Andrechak, Jason C.; Hayes, Brandon H.; Kadu, Siddhant; Zhang, William; Pan, Ruby; Vashisth, Manasvita; Irianto, Jerome; Alvey, Cory M.; Ma, Leyuan; et al (April 2023, Nature Biomedical Engineering)

   In solid tumours, the abundance of macrophages is typically associated with a poor prognosis. However, macrophage clusters in tumour-cell nests have been associated with survival in some tumour types. Here, by using tumour organoids comprising macrophages and cancer cells opsonized via a monoclonal antibody, we show that highly ordered clusters of macrophages cooperatively phagocytose cancer cells to suppress tumour growth. In mice with poorly immunogenic tumours, the systemic delivery of macrophages with signal-regulatory protein alpha (SIRPα) genetically knocked out or else with blockade of the CD47–SIRPα macrophage checkpoint was combined with the monoclonal antibody and subsequently triggered the production of endogenous tumour-opsonizing immunoglobulin G, substantially increased the survival of the animals and helped confer durable protection from tumour re-challenge and metastasis. Maximizing phagocytic potency by increasing macrophage numbers, by tumour-cell opsonization and by disrupting the phagocytic checkpoint CD47– 

   more » « less
4. Micro-engineering and nano-engineering approaches to investigate tumour ecosystems

   https://doi.org/10.1038/s41568-023-00593-3  

   Kim, Mijin; Panagiotakopoulou, Magdalini; Chen, Chen; Ruiz, Stephen B; Ganesh, Karuna; Tammela, Tuomas; Heller, Daniel A (September 2023, Nature Reviews Cancer)
5. The blood–brain barrier and blood–tumour barrier in brain tumours and metastases

   https://doi.org/10.1038/s41568-019-0205-x  

   Arvanitis, Costas D.; Ferraro, Gino B.; Jain, Rakesh K. (January 2020, Nature Reviews Cancer)

   null (Ed.)