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Abstract Biomolecule isolation is a crucial process in diverse biomedical and biochemical applications, including diagnostics, therapeutics, research, and manufacturing. Recently, MXenes, a novel class of two‐dimensional nanomaterials, have emerged as promising adsorbents for this purpose due to their unique physicochemical properties. These biocompatible and antibacterial nanomaterials feature a high aspect ratio, excellent conductivity, and versatile surface chemistry. This timely review explores the potential of MXenes for isolating a wide range of biomolecules, such as proteins, nucleic acids, and small molecules, while highlighting key future research trends and innovative applications poised to transform the field. This review provides an in‐depth discussion of various synthesis methods and functionalization techniques that enhance the specificity and efficiency of MXenes in biomolecule isolation. In addition, the mechanisms by which MXenes interact with biomolecules are elucidated, offering insights into their selective adsorption and customized separation capabilities. This review also addresses recent advancements, identifies existing challenges, and examines emerging trends that may drive the next wave of innovation in this rapidly evolving area.
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This content will become publicly available on May 5, 2026
Bio‐Functionalized MXenes: Synthesis and Versatile Applications
Abstract MXenes exhibit remarkable properties, including high electrical conductivity, tunable surface chemistry, outstanding mechanical strength, and notable hydrophilicity. Recent advancements in bio‐functionalization have further enhanced these intrinsic characteristics, unlocking unprecedented opportunities for MXenes across a wide spectrum of applications in both biomedical and environmental domains. This review provides an in‐depth analysis of the synthesis strategies and functionalization techniques that improve MXenes' biocompatibility and expand their potential uses in cutting‐edge applications, including implantable and wearable devices, drug delivery systems, cancer therapies, tissue engineering, and advanced sensing technologies. Moreover, the review explores the utility of bio‐functionalized MXenes in areas such as corrosion protection, water purification, and food safety sensors, underscoring their versatility in addressing urgent global challenges. By conducting a critical evaluation of current research, this review not only highlights the immense potential of bio‐functionalized MXenes but also identifies pivotal gaps in the literature, offering clear pathways for future exploration and innovation in this rapidly evolving field.
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- Award ID(s):
- 2134607
- PAR ID:
- 10599850
- Publisher / Repository:
- Wiley Blackwell (John Wiley & Sons)
- Date Published:
- Journal Name:
- Advanced Healthcare Materials
- Volume:
- 14
- Issue:
- 15
- ISSN:
- 2192-2640
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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