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We investigated sex-specific responses to hyperoxia-induced acute lung injury (HALI) in rats. Female rats exhibited attenuated severity, with less pleural effusion, pulmonary edema, and apoptosis than males. Studies in isolated mitochondria, lung tissue homogenates, and isolated lungs indicate that this attenuated severity is associated with mitochondrial adaptations and enhanced tissue H2O2scavenging capacity. These findings underscore the importance of sex as a biological variable and identify mitochondrial complex II as a potential HALI therapeutic target.
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Mitochondrial function in lungs of rats with different susceptibilities to hyperoxia-induced acute lung injury
We assessed lung tissue mitochondrial bioenergetics in rats with tolerance (H-T) or susceptibility (H-S) to hyperoxia-induced ARDS. Results from studies in isolated mitochondria, tissue homogenate, and isolated perfused lungs show that mitochondrial bioenergetics are differentially altered in H-T and H-S lungs suggesting a potential role for mitochondrial bioenergetics in hyperoxia-induced ARDS. Results are clinically relevant since hyperoxia exposure is a primary therapy for patients with ARDS, and differential sensitivity to hyperoxia surely occurs in humans.
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- Award ID(s):
- 2153387
- PAR ID:
- 10600571
- Publisher / Repository:
- APS
- Date Published:
- Journal Name:
- Journal of Applied Physiology
- Volume:
- 137
- Issue:
- 2
- ISSN:
- 8750-7587
- Page Range / eLocation ID:
- 233 to 253
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
-
Accepted Manuscript
- Journal Article:
- https://doi.org/10.1152/japplphysiol.00243.2024
