More Like this

1. Enantioseparation and racemization of α‐aryl‐α‐fluoroacetonitriles

   https://doi.org/10.1002/chir.23367  

   Steber, Sarah E.; Pham, Angelette N.; Nelson, Eryn; Wolf, Christian (December 2021, Chirality)
2. Deoxygenative α-alkylation and α-arylation of 1,2-dicarbonyls

   https://doi.org/10.1039/d0sc03118f  

   Jin, Shengfei; Dang, Hang T.; Haug, Graham C.; Nguyen, Viet D.; Arman, Hadi D.; Larionov, Oleg V. (September 2020, Chemical Science)

   null (Ed.)

   Construction of C–C bonds at the α-carbon is a challenging but synthetically indispensable approach to α-branched carbonyl motifs that are widely represented among drugs, natural products, and synthetic intermediates. Here, we describe a simple approach to generation of boron enolates in the absence of strong bases that allows for introduction of both α-alkyl and α-aryl groups in a reaction of readily accessible 1,2-dicarbonyls and organoboranes. Obviation of unselective, strongly basic and nucleophilic reagents permits carrying out the reaction in the presence of electrophiles that intercept the intermediate boron enolates, resulting in two new α-C–C bonds in a tricomponent process. 

   more » « less
3. An organocascade approach to α,α-chlorofluoroalcohols

   https://doi.org/10.1016/j.tetlet.2015.05.107  

   Hayes, Montgomery D.; Rodríguez-Alvarado, Melanie; Brenner-Moyer, Stacey E. (August 2015, Tetrahedron Letters)
4. Synthesis of α,α’-linked penta- and septaheterocycles by tandem Suzuki coupling

   https://doi.org/10.1142/S1088424618501080  

   Zafar, Hadiqa; Brewster, James T.; Wight, Christopher D.; McVeigh, Matthew; Steinbrück, Axel; Lynch, Vincent M.; Sessler, Jonathan L. (January 2019, Journal of Porphyrins and Phthalocyanines)
5. Absolute Configuration and Polymorphism of 2-Phenylbutyramide and α-Methyl-α-phenylsuccinimide

   https://doi.org/10.1021/cg500284q  

   Khrustalev, Victor N.; Sandhu, Bhupinder; Bentum, Samuel; Fonari, Alexandr; Krivoshein, Arcadius V.; Timofeeva, Tatiana V. (May 2014, Crystal Growth & Design)