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The neutrino research program in the coming decades will require improved precision. A major source of uncertainty is the interaction of neutrinos with nuclei that serve as targets for such experiments. Broadly speaking, this interaction often depends, e.g., for charge-current quasielastic scattering, on the combination of “nucleon physics,” expressed by form factors, and “nuclear physics,” expressed by a nuclear model. It is important to get a good handle on both. We present a fully analytic implementation of the correlated Fermi gas model for electron-nucleus and charge-current quasielastic neutrino-nucleus scattering. The implementation is used to compare separately form factors and nuclear model effects for both electron-carbon and neutrino-carbon scattering data. Published by the American Physical Society2025
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Spatiotemporal dynamics of nucleocytoplasmic transport
Nucleocytoplasmic transport is essential for cellular function, presenting a canonical example of rapid molecular sorting inside cells. It consists of a coordinated interplay between import/export of molecules in/out the cell nucleus. Here, we investigate the role of spatiotemporal dynamics of the nucleocytoplasmic transport and its regulation. We develop a biophysical model that captures the main features of the nucleocytoplasmic transport, in particular, its regulation through the Ran cycle. Our model yields steady-state profiles for the molecular components of the Ran cycle, their relaxation times, as well as the nuclear-to-cytoplasmic molecule ratio. We show that these quantities are affected by their spatial dynamics and heterogeneity within the nucleus. Specifically, we find that the spatial nonuniformity of Ran guanine exchange factor (RanGEF)—particularly its proximity to the nuclear envelope—increases the Ran content in the nucleus. We further show that RanGEF's accumulation near the nuclear envelope results from its intrinsic dynamics as a nuclear cargo, transported by the Ran cycle itself. Overall, our work highlights the critical role of molecular spatial dynamics in cellular processes and proposes new avenues for theoretical and experimental inquiries into the nucleocytoplasmic transport. Published by the American Physical Society2024
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- PAR ID:
- 10611813
- Publisher / Repository:
- APS
- Date Published:
- Journal Name:
- Physical Review Research
- Volume:
- 6
- Issue:
- 4
- ISSN:
- 2643-1564
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
-
Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.1103/PhysRevResearch.6.043022
