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1. Atypical Carboxysome Loci: JEEPs or Junk?

   https://doi.org/10.3389/fmicb.2022.872708  

   Sutter, Markus; Kerfeld, Cheryl A.; Scott, Kathleen M. (May 2022, Frontiers in Microbiology)

   Carboxysomes, responsible for a substantial fraction of CO 2 fixation on Earth, are proteinaceous microcompartments found in many autotrophic members of domain Bacteria , primarily from the phyla Proteobacteria and Cyanobacteria . Carboxysomes facilitate CO 2 fixation by the Calvin-Benson-Bassham (CBB) cycle, particularly under conditions where the CO 2 concentration is variable or low, or O 2 is abundant. These microcompartments are composed of an icosahedral shell containing the enzymes ribulose 1,5-carboxylase/oxygenase (RubisCO) and carbonic anhydrase. They function as part of a CO 2 concentrating mechanism, in which cells accumulate HCO 3 − in the cytoplasm via active transport, HCO 3 − enters the carboxysomes through pores in the carboxysomal shell proteins, and carboxysomal carbonic anhydrase facilitates the conversion of HCO 3 − to CO 2 , which RubisCO fixes. Two forms of carboxysomes have been described: α-carboxysomes and β-carboxysomes, which arose independently from ancestral microcompartments. The α-carboxysomes present in Proteobacteria and some Cyanobacteria have shells comprised of four types of proteins [CsoS1 hexamers, CsoS4 pentamers, CsoS2 assembly proteins, and α-carboxysomal carbonic anhydrase (CsoSCA)], and contain form IA RubisCO (CbbL and CbbS). In the majority of cases, these components are encoded in the genome near each other in a gene locus, and transcribed together as an operon. Interestingly, genome sequencing has revealed some α-carboxysome loci that are missing genes encoding one or more of these components. Some loci lack the genes encoding RubisCO, others lack a gene encoding carbonic anhydrase, some loci are missing shell protein genes, and in some organisms, genes homologous to those encoding the carboxysome-associated carbonic anhydrase are the only carboxysome-related genes present in the genome. Given that RubisCO, assembly factors, carbonic anhydrase, and shell proteins are all essential for carboxysome function, these absences are quite intriguing. In this review, we provide an overview of the most recent studies of the structural components of carboxysomes, describe the genomic context and taxonomic distribution of atypical carboxysome loci, and propose functions for these variants. We suggest that these atypical loci are JEEPs, which have modified functions based on the presence of Just Enough Essential Parts. 

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2. Constraints on the Hubble constant from supernova Refsdal’s reappearance

   https://doi.org/10.1126/science.abh1322  

   Kelly, Patrick L.; Rodney, Steven; Treu, Tommaso; Oguri, Masamune; Chen, Wenlei; Zitrin, Adi; Birrer, Simon; Bonvin, Vivien; Dessart, Luc; Diego, Jose M.; et al (June 2023, Science)

   The gravitationally lensed supernova Refsdal appeared in multiple images produced through gravitational lensing by a massive foreground galaxy cluster. After the supernova appeared in 2014, lens models of the galaxy cluster predicted that an additional image of the supernova would appear in 2015, which was subsequently observed. We use the time delays between the images to perform a blinded measurement of the expansion rate of the Universe, quantified by the Hubble constant (H₀). Using eight cluster lens models, we infer $H_0={64.8}_{-4.3}^{+4.4}\text{ kilometers per second per megaparsec}$. Using the two models most consistent with the observations, we find $H_0={66.6}_{-3.3}^{+4.1}\text{ kilometers per second per megaparsec}$. The observations are best reproduced by models that assign dark-matter halos to individual galaxies and the overall cluster. 

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3. Observation of $\text{γ}\text{γ}\to \text{τ}\text{τ}$ in proton–proton collisions and limits on the anomalous electromagnetic moments of the τ lepton

   https://doi.org/10.1088/1361-6633/ad6fcb  

   CMS_Collaboration, The (September 2024, Reports on Progress in Physics)

   Abstract The production of a pair of τ leptons via photon–photon fusion, $\text{γ}\text{γ}\to \text{τ}\text{τ}$, is observed for the first time in proton–proton collisions, with a significance of 5.3 standard deviations. This observation is based on a data set recorded with the CMS detector at the LHC at a center-of-mass energy of 13 TeV and corresponding to an integrated luminosity of 138 fb⁻¹. Events with a pair of τ leptons produced via photon–photon fusion are selected by requiring them to be back-to-back in the azimuthal direction and to have a minimum number of charged hadrons associated with their production vertex. The τ leptons are reconstructed in their leptonic and hadronic decay modes. The measured fiducial cross section of $\text{γ}\text{γ}\to \text{τ}\text{τ}$is ${\sigma }_{\text{obs}}^{\text{fid}}={12.4}_{-3.1}^{+3.8}\text{fb}$. Constraints are set on the contributions to the anomalous magnetic moment ( $a_{\text{τ}}$) and electric dipole moments ( $d_{\text{τ}}$) of the τ lepton originating from potential effects of new physics on the $\text{γ}\text{τ}\text{τ}$vertex: $a_{\text{τ}}={0.0009}_{-0.0031}^{+0.0032}$and $|d_{\text{τ}}|<2.9\times {10}^{-17}e\text{cm}$(95% confidence level), consistent with the standard model. 

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4. Observation of a pseudoscalar excess at the top quark pair production threshold

   https://doi.org/10.1088/1361-6633/adf7d3  

   Collaboration, The_CMS (August 2025, Reports on Progress in Physics)

   Abstract A search for resonances in top quark pair ( $\mathrm{t}\bar{\mathrm{t}}$) production in final states with two charged leptons and multiple jets is presented, based on proton–proton collision data collected by the CMS experiment at the CERN LHC at $\sqrt{s}=13\text{TeV}$, corresponding to 138 fb⁻¹. The analysis explores the invariant mass of the $\mathrm{t}\bar{\mathrm{t}}$system and two angular observables that provide direct access to the correlation of top quark and antiquark spins. A significant excess of events is observed near the kinematic $\mathrm{t}\bar{\mathrm{t}}$threshold compared to the non-resonant production predicted by fixed-order perturbative quantum chromodynamics (pQCD). The observed enhancement is consistent with the production of a color-singlet pseudoscalar ( ${}^1{\text{S}}_0^{\left[1\right]}$) quasi-bound toponium state, as predicted by non-relativistic quantum chromodynamics. Using a simplified model for ${}^1{\text{S}}_0^{\left[1\right]}$toponium, the cross section of the excess above the pQCD prediction is measured to be $8.8{}_{-1.4}^{+1.2}\text{pb}$. 

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5. Measurement of off-shell Higgs boson production in the $H^{\ast }\to ZZ\to 4\ell$ decay channel using a neural simulation-based inference technique in 13 TeV pp collisions with the ATLAS detector

   https://doi.org/10.1088/1361-6633/adcd9a  

   The_ATLAS_Collaboration (May 2025, Reports on Progress in Physics)

   Abstract A measurement of off-shell Higgs boson production in the $H^{\ast }\to ZZ\to 4\ell$decay channel is presented. The measurement uses 140 fb⁻¹of proton–proton collisions at $\sqrt{s}=13$TeV collected by the ATLAS detector at the Large Hadron Collider and supersedes the previous result in this decay channel using the same dataset. The data analysis is performed using a neural simulation-based inference method, which builds per-event likelihood ratios using neural networks. The observed (expected) off-shell Higgs boson production signal strength in the $ZZ\to 4\ell$decay channel at 68% CL is ${0.87}_{-0.54}^{+0.75}$( ${1.00}_{-0.95}^{+1.04}$). The evidence for off-shell Higgs boson production using the $ZZ\to 4\ell$decay channel has an observed (expected) significance of 2.5σ(1.3σ). The expected result represents a significant improvement relative to that of the previous analysis of the same dataset, which obtained an expected significance of 0.5σ. When combined with the most recent ATLAS measurement in the $ZZ\to 2\ell 2\nu$decay channel, the evidence for off-shell Higgs boson production has an observed (expected) significance of 3.7σ(2.4σ). The off-shell measurements are combined with the measurement of on-shell Higgs boson production to obtain constraints on the Higgs boson total width. The observed (expected) value of the Higgs boson width at 68% CL is ${4.3}_{-1.9}^{+2.7}$( ${4.1}_{-3.4}^{+3.5}$) MeV. 

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