Abstract ObjectivesBlack older adults have a higher vascular burden compared to non‐Hispanic White (NHW) older adults, which may put them at risk for a form of depression known as vascular depression (VaDep). The literature examining VaDep in Black older adults is sparse. The current study addressed this important gap by examining whether vascular burden was associated with depressive symptoms in Black older adults. MethodsParticipants included 113 Black older adults from the Healthy Brain Project, a substudy of the Health, Aging, and Body Composition Study. In multiple regression analyses, clinical vascular burden (sum of vascular conditions) and white matter hyperintensity (WMH) volume predicted depressive symptoms as measured by the Center for Epidemiologic Studies Depression Scale, controlling for demographic variables. Follow‐up analyses compared the associations in the Black subsample and in 179 NHW older adults. ResultsHigher total WMH volume, but not clinically‐defined vascular burden, predicted higher concurrent depressive symptoms and higher average depressive symptoms over 4 years. Similar associations were found between uncinate fasciculus (UF) WMHs and concurrent depressive symptoms and between superior longitudinal fasciculus WMHs and average depressive symptoms. The association between depressive symptoms and UF WMH was stronger in Black compared to NHW individuals. ConclusionThis research is consistent with the VaDep hypothesis and extends it to Black older adults, a group that has historically been underrepresented in the literature. Results highlight WMH in the UF as particularly relevant to depressive symptoms in Black older adults and suggest this group may be particularly vulnerable to the negative effects of WMH.
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Brief Report: Convergence and Discrepancy Between Self- and Informant-Reported Depressive Symptoms in Young Autistic Adults
Purpose Autistic individuals exhibit elevated rates of depression; however, assessment is complicated by clinical presenta- tions and limited validation in this population. Recent work has demonstrated the utility of the Beck Depression Inventory (BDI-II) in screening for depression in ASD. The current study extends this work by examining the convergence and diver- gence of self- and informant-reported depression in autistic (n = 258) and non-autistic (n = 255) young adults. Methods Participants completed the BDI-II as a self-report measure of depression; informants completed the Achenbach Adult Behavior Checklist. Analyses probed for between-group differences in rates of depression symptoms, convergence between self- and informant-reported depression, and discrepancy between self- and informant-reported depression. Results Results indicated significantly higher rates of depressive symptoms in the autistic group. Convergence was signifi- cant in both groups, with significantly greater agreement in the autistic group. There was differential divergence, with the autistic group reporting significantly lower scores relative to informants, and the non-autistic group reporting significantly higher scores relative to informants. Conclusions Consistent with prior reports, results suggest that depression rates are elevated in autism. Additionally, while the BDI-II may be adequate for screening depressive symptoms in speaking autistic young adults, eliciting information from a close adult informant provides valuable diagnostic information, due to clinically critical concerns about underreporting in this population. Although controlled in analyses, between-group differences in gender, age, race, and informant identity, and a predominantly White and non-Latinx sample, limit the generalizability of these results.
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- Award ID(s):
- 2152202
- PAR ID:
- 10613625
- Publisher / Repository:
- NSF Public Access Repository
- Date Published:
- Journal Name:
- Journal of Autism and Developmental Disorders
- ISSN:
- 0162-3257
- Subject(s) / Keyword(s):
- Depression Self-report Informant-report Convergence Discrepancy
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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