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Abstract As a participant in the joint CASP13‐CAPRI46 assessment, the ClusPro server debuted its new template‐based modeling functionality. The addition of this feature, called ClusPro TBM, was motivated by the previous CASP‐CAPRI assessments and by the proven ability of template‐based methods to produce higher‐quality models, provided templates are available. In prior assessments, ClusPro submissions consisted of models that were produced via free docking of pre‐generated homology models. This method was successful in terms of the number of acceptable predictions across targets; however, analysis of results showed that purely template‐based methods produced a substantially higher number of medium‐quality models for targets for which there were good templates available. The addition of template‐based modeling has expanded ClusPro's ability to produce higher accuracy predictions, primarily for homomeric but also for some heteromeric targets. Here we review the newest additions to the ClusPro web server and discuss examples of CASP‐CAPRI targets that continue to drive further development. We also describe ongoing work not yet implemented in the server. This includes the development of methods to improve template‐based models and the use of co‐evolutionary information for data‐assisted free docking.
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This content will become publicly available on December 1, 2025
Automated physics-based modeling of construction equipment through data fusion
Physics-based simulations are essential for designing autonomous construction equipment, but preparing models is time-consuming, requiring the integration of mechanical and geometric data. Current automatic modeling methods for modular robots are inadequate for construction equipment. This paper explores automating the modeling process by integrating mechanical data into 3D computer-aided design (CAD) models. A template library is developed with hierarchy and joint templates specific for equipment. During model generation, appropriate templates are selected based on the equipment type. Unspecified joint template data is extracted from technical specifications using a large language model (LLM). The 3D CAD model is then converted into a Universal Scene Description (USD) model. Users can adjust the part names and hierarchy within the USD model to align with the hierarchy template, and joint data is automatically integrated, resulting in a simulation-ready model. This method reduces modeling time by over 87 % compared to manual methods, while maintaining accuracy.
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- Award ID(s):
- 2152163
- PAR ID:
- 10613639
- Publisher / Repository:
- Elsevier B.V.
- Date Published:
- Journal Name:
- Automation in Construction
- Volume:
- 168
- Issue:
- PB
- ISSN:
- 0926-5805
- Page Range / eLocation ID:
- 105880
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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