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Title: Conserved components of the macroautophagy machinery in Caenorhabditis elegans
Abstract Macroautophagy involves the sequestration of cytoplasmic contents in a double-membrane autophagosome and its subsequent delivery to lysosomes for degradation and recycling. In Caenorhabditis elegans, autophagy participates in diverse processes such as stress resistance, cell fate specification, tissue remodeling, aging, and adaptive immunity. Genetic screens in C. elegans have identified a set of metazoan-specific autophagy genes that form the basis for our molecular understanding of steps unique to the autophagy pathway in multicellular organisms. Suppressor screens have uncovered multiple mechanisms that modulate autophagy activity under physiological conditions. C. elegans also provides a model to investigate how autophagy activity is coordinately controlled at an organismal level. In this chapter, we will discuss the molecular machinery, regulation, and physiological functions of autophagy, and also methods utilized for monitoring autophagy during C. elegans development.  more » « less
Award ID(s):
2223241 2215946 9805868
PAR ID:
10632664
Author(s) / Creator(s):
;
Editor(s):
Greenwald, I
Publisher / Repository:
Oxford
Date Published:
Journal Name:
GENETICS
Volume:
229
Issue:
4
ISSN:
1943-2631
Subject(s) / Keyword(s):
autophagy macroautophagy
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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