skip to main content
US FlagAn official website of the United States government
dot gov icon
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
https lock icon
Secure .gov websites use HTTPS
A lock ( lock ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.


This content will become publicly available on October 10, 2026

Title: Shape dynamics of nearly spherical, multicomponent vesicles under shear flow
In biology, cells undergo deformations under the action of flow caused by the fluid surrounding them. These flows lead to shape changes and instabilities that have been explored in detail for single component vesicles. However, cell membranes are often multicomponent in nature, made up of multiple phospholipids and cholesterol mixtures that give rise to interesting thermodynamics and fluid mechanics. Our work analyses shear flow around a multicomponent vesicle using a small-deformation theory based on vector and scalar spherical harmonics. We set up the problem by laying out the governing momentum equations and the traction balance arising from the phase separation and bending. These equations are solved along with a Cahn–Hilliard equation that governs the coarsening dynamics of the phospholipid–cholesterol mixture. We provide a detailed analysis of the vesicle dynamics (e.g. tumbling, breathing, tank-treading and swinging/phase-treading) in two regimes – when flow is faster than coarsening dynamics (Péclet number$${\textit{Pe}} \gg 1$$) and when the two time scales are comparable ($$\textit{Pe} \sim O(1)$$) – and provide a discussion on when these behaviours occur. The analysis aims to provide an experimentalist with important insights pertaining to the phase separation dynamics and their effect on the deformation dynamics of a vesicle.  more » « less
Award ID(s):
2147559
PAR ID:
10647835
Author(s) / Creator(s):
;
Publisher / Repository:
Cambridge University Press
Date Published:
Journal Name:
Journal of Fluid Mechanics
Volume:
1020
ISSN:
0022-1120
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
More Like this
  1. We compute steady planar incompressible flows and wall shapes that maximize the rate of heat transfer ($$Nu$$) between hot and cold walls, for a given rate of viscous dissipation by the flow ($$Pe^2$$), with no-slip boundary conditions at the walls. In the case of no flow, we show theoretically that the optimal walls are flat and horizontal, at the minimum separation distance. We use a decoupled approximation to show that flat walls remain optimal up to a critical non-zero flow magnitude. Beyond this value, our computed optimal flows and wall shapes converge to a set of forms that are invariant except for a$$Pe^{-1/3}$$scaling of horizontal lengths. The corresponding rate of heat transfer$$Nu \sim Pe^{2/3}$$. We show that these scalings result from flows at the interface between the diffusion-dominated and convection-dominated regimes. We also show that the separation distance of the walls remains at its minimum value at large$$Pe$$. 
    more » « less
  2. The motion of a disk in a Langmuir film bounding a liquid substrate is a classical hydrodynamic problem, dating back to Saffman (J. Fluid Mech., vol. 73, 1976, p. 593) who focused upon the singular problem of translation at large Boussinesq number,$${\textit {Bq}}\gg 1$$. A semianalytic solution of the dual integral equations governing the flow at arbitrary$${\textit {Bq}}$$was devised by Hugheset al.(J. Fluid Mech., vol. 110, 1981, p. 349). When degenerated to the inviscid-film limit$${\textit {Bq}}\to 0$$, it produces the value$$8$$for the dimensionless translational drag, which is$$50\,\%$$larger than the classical$$16/3$$-value corresponding to a free surface. While that enhancement has been attributed to surface incompressibility, the mathematical reasoning underlying the anomaly has never been fully elucidated. Here we address the inviscid limit$${\textit {Bq}}\to 0$$from the outset, revealing a singular mechanism where half of the drag is contributed by the surface pressure. We proceed beyond that limit, considering a nearly inviscid film. A naïve attempt to calculate the drag correction using the reciprocal theorem fails due to an edge singularity of the leading-order flow. We identify the formation of a boundary layer about the edge of the disk, where the flow is primarily in the azimuthal direction with surface and substrate stresses being asymptotically comparable. Utilising the reciprocal theorem in a fluid domain tailored to the asymptotic topology of the problem produces the drag correction$$(8\,{\textit {Bq}}/{\rm \pi} ) [ \ln (2/{\textit {Bq}}) + \gamma _E+1]$$,$$\gamma _E$$being the Euler–Mascheroni constant. 
    more » « less
  3. Flow dynamics around a stationary flat plate near a free surface is investigated using time-resolved two-dimensional particle image velocimetry. The study examines variations in angle of attack ($$\theta =0^\circ {-}35^\circ {}$$), Reynolds number ($$Re$$$$\approx$$$$10^3$$$$-$$3$$\times$$$$10^4$$) and plate proximity to the free surface ($$H^*$$). Under symmetric boundary conditions ($$H^*\geqslant {15}$$), increasing$$\theta$$intensifies fluid–plate interaction, resulting in the shedding of leading-edge and trailing-edge vortices (LEV and TEV), each characterised by distinct strengths and sizes. In both symmetric ($$H^*\geqslant {15}$$) and asymmetric ($$H^*=5$$) boundary conditions at$$\theta \lt 5^\circ {}$$, fluid flow follows the contour of the plate, unaffected by Reynolds number. However, at$$H^*=5$$, three flow regimes emerge: the first Coanda effect (CI), regular shedding (RS) and the second Coanda effect (CII), each influenced by$$\theta$$and$$Re$$. The CI regime dominates at lower angles ($$5^\circ {}\leqslant \theta \leqslant 25^\circ {}$$) and$$Re \leqslant 12\,500$$, featuring a Coanda-induced jet-like flow pattern. As the Reynolds number increases, the flow transitions into the RS regime, leading to detachment from the upper surface of the plate. This detachment results in the formation of LEV and TEV in the wake, along with surface deformation, secondary vortices and wavy shear layers beneath the free surface. At$$22\,360\lt Re \leqslant 32\,200$$and$$5^\circ {} \leqslant \theta \leqslant 25^\circ {}$$, in the CII regime, significant surface deformation causes the Coanda effect to reattach the flow to the plate, forming a unique jet-like flow. 
    more » « less
  4. Except in the trivial case of spatially uniform flow, the advection–diffusion operator of a passive scalar tracer is linear and non-self-adjoint. In this study, we exploit the linearity of the governing equation and present an analytical eigenfunction approach for computing solutions to the advection–diffusion equation in two dimensions given arbitrary initial conditions, and when the advecting flow field at any given time is a plane parallel shear flow. Our analysis illuminates the specific role that the non-self-adjointness of the linear operator plays in the solution behaviour, and highlights the multiscale nature of the scalar mixing problem given the explicit dependence of the eigenvalue–eigenfunction pairs on a multiscale parameter$$q=2{\rm i}k\,{\textit {Pe}}$$, where$$k$$is the non-dimensional wavenumber of the tracer in the streamwise direction, and$${\textit {Pe}}$$is the Péclet number. We complement our theoretical discussion on the spectra of the operator by computing solutions and analysing the effect of shear flow width on the scale-dependent scalar decay of tracer variance, and characterize the distinct self-similar dispersive processes that arise from the shear flow dispersion of an arbitrarily compact tracer concentration. Finally, we discuss limitations of the present approach and future directions. 
    more » « less
  5. Let$$G$$be a split reductive group over the ring of integers in a$$p$$-adic field with residue field$$\mathbf {F}$$. Fix a representation$$\overline {\rho }$$of the absolute Galois group of an unramified extension of$$\mathbf {Q}_p$$, valued in$$G(\mathbf {F})$$. We study the crystalline deformation ring for$$\overline {\rho }$$with a fixed$$p$$-adic Hodge type that satisfies an analog of the Fontaine–Laffaille condition for$$G$$-valued representations. In particular, we give a root theoretic condition on the$$p$$-adic Hodge type which ensures that the crystalline deformation ring is formally smooth. Our result improves on all known results for classical groups not of type A and provides the first such results for exceptional groups. 
    more » « less