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Abstract High‐resolution separation systems are essential for the analysis of complex mixtures in a wide variety of application areas. To increase resolution, multidimensional chromatographic techniques have been one key solution. Supercritical fluid chromatography provides a unique opportunity in these multidimensional separations based on its potential for high solvent compatibility, rapid duty cycles, and orthogonality to other separation modes. This review focuses on two‐dimensional chromatography methods from the past decade that use supercritical fluid chromatography because of these advantages. Valving schemes and modulation strategies used to interface supercritical fluid chromatography with other liquid chromatography and gas chromatography techniques are described. Particular applications of multidimensional separations using supercritical fluid chromatography for the analysis of oils and chiral separations of pharmaceutical compounds are highlighted. Limitations of and a potential trajectory for supercritical fluid chromatography in this field are also discussed.
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This content will become publicly available on November 12, 2026
Particle-laden filaments from a draining suspension
Particle-laden filaments form on the fluid–fluid interface when a suspension drains from a vertical Hele-Shaw cell. This instability is driven by the competition between viscous stresses on highly confined particles and stabilizing capillarity.
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- PAR ID:
- 10648818
- Publisher / Repository:
- Royal Society of Chemistry
- Date Published:
- Journal Name:
- Soft Matter
- Volume:
- 21
- Issue:
- 44
- ISSN:
- 1744-683X
- Page Range / eLocation ID:
- 8479 to 8488
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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