History of Health at Cayo Santiago—An Investigation of Environmental and Genetic Influences on the Skeletal Remains of the Introduced Rhesus Macaque ( Macaca mulatta ) Colony
Title: History of Health at Cayo Santiago—An Investigation of Environmental and Genetic Influences on the Skeletal Remains of the Introduced Rhesus Macaque ( Macaca mulatta ) Colony
ABSTRACT The Cayo Santiago rhesus macaque colony is a renowned primate population that has experienced significant natural and anthropogenic ecological variation in their 85‐year history. Demographic and familial information is also tracked and collated for the majority of monkeys. Thus, the health history of rhesus macaques at Cayo Santiago should reflect the impacts of both environmental and genetic factors. In this study, we utilized a sample of skeletal remains comprised of 2787 individuals (1571 females, 1091 males), born between 1938 and 2017 from the derived skeletal collection of the primate colony to assess variation in survivorship, pathology, bone mineral density (BMD), and dental eruption status, in the context of hurricane impacts, nutritional fluctuations, and matriline genealogy. Results demonstrated that rhesus macaques at Cayo Santiago exhibit a range of skeletal pathologies that encompass biomedical and archaeological significance, multiple etiologies, severities, locations, and types, in addition to a secular trend of declining BMD that is hypothesized to reflect decreasing physical activity levels under increasing population densities. Specifically, hurricane impacts were found to increase the rate of systemic disease, decrease BMD in young adults, and delay eruption of the primary dentition. Certain matrilines exhibited heightened levels of systemic disease at early ages while others exhibited greater rates of congenital disease. Early‐life adversity, through the experience of major hurricanes, may enhance inflammatory pathways, heightening the risk of disease and accelerating the aging process leading to reduced BMD. Such impacts may underly greater levels of observed infection post‐hurricane through intensification of pathogen transmission and disease rates brought on by hurricane‐adaptive social strategies that favor closer proximity. Familial susceptibility to disease indicates heritable host genetic factors are likely influencing disease patterning in the population. A cluster of congenital diseases may most convincingly illustrate this, or alternatively reflects low levels of genetic diversity in the population. more »« less
Wang, Qian; Francis, George
(, American Journal of Primatology)
Bales, Karen
(Ed.)
Abstract The Cayo Santiago rhesus macaque colony represents one of the most important nonhuman primate resources since their introduction to the Caribbean area in 1938. The 85 years of continuing existence along with the comprehensive database of the rhesus colony and the derived skeletal collections have provided and will continue to provide a powerful tool to test hypotheses about adaptive and evolutionary mechanisms in both biology and medicine.
Zhao, Martin Q.; Widener, Ethan R.; Francis, George; and Wang, Qian
(, Proceedings of the Second International Conference on Innovations in Computing Research (ICR’23). Lecture Notes in Networks and Systems, vol 721. Springer, Cham.)
Daimi, K.; and Sadoon, A. Al
(Ed.)
In this paper, we introduce an NSF funded project that aims to develop a database that integrates genetic, environmental and age-related information to study their effects on health conditions of a rhesus monkey colony at Cayo Santiago, Puerto Rico, which has been founded since 1938. In this project, we will combine the osteology data with the rich genealogy and demographic information into a searchable and computer-interoperable knowledge model accessible through user-friendly interfaces. Backed by the integrated database, this system will provide researchers and the public information from the Cayo Santiago rhesus colony and the derived skeletal collection, a powerful non-human model for datamining to study human disease. Undergraduate and graduate students from diverse communities have been incorporated into research and development activities. Related materials are used as case studies in relevant classes at Mercer University to help train these undergraduate students into problem solvers.
Zhao, Martin Q; Kaur, Mehakpreet; Kundu, Soumik; Gong, Rui; Novak, Cooper; Wang, Qian
(, The 93rd Annual Conference of American Association of Biological Anthropology)
The rich records of Rhesus macaques at Cayo Santiago (CS) with detailed information of individual and family relationships enables extended genetic analyses of the reproductive history of the colony. As a part of a collaborative effort to build a Knowledge Model of the history of health of the CS Rhesus colony, this study further delves into the intricate social group interactions and reproduction dynamics to provide an integrated perspective for a deeper understanding of familial connections and genetic aggregations. Leveraging matrilineal lineage developed from previous work and patrilineal tracing made available since mid-1970’s, as well as inter-group transfer data, this study attempted to provide retrospective views of group evolution history, with an emphasis on dyad interactions regarding their natal and transferred groups. Employing tools and techniques popular in social community analysis, including graph database and Gephi, this study conducted a comparative analysis focused on animals born between 2005 and 2014. Preliminary results indicated that communities identified by using Gephi matched well with census records, while deviations from historical sketches of group evolution summaries existed as well. Upcoming results from using Neo4j, a graph database system, will be compared with these findings, which can be integrated more smoothly with CSViewer for Analysts, the graphical user interfaces for the CS Knowledge Model to be introduced in a workshop at AABA 2024 annual meeting. Findings of this research can help add one more perspective to pathological studies seeking correlations with environmental factors such as food provision and natural disasters like hurricanes.
Growth modeling is a key aspect of statistical analysis, particularly in fields such as biology, economics, and social sciences. In primate development studies, ontogeny is a well-known phenomenon that skeletal growth tends to stop at a certain age. Bone dimension measures of over 1200 skeletal sets derived from the Cayo Santiago (CS) rhesus colony were recently collected by a collaborative effort supported through NSF grants. These measures provided a valuable resource for extending a knowledge model for primate skeletal development regarding ontogeny, and variations based on sex and matrilineal lineage. This paper presents initial results of a custom regression model proposed, as well as model comparisons with other popular models used in similar line fitting tasks. Related data analytics and visualization support as implemented in the CSViewer for Analysts system are also described.
Kohn, Luci; Schulz, Kurt; Kensler, Terry B; Maldonado, Elizabeth; Guatelli‐Steinberg, Debbie; Zhao, Martin Q; Francis, George; Wang, Qian
(, American Journal of Primatology)
ABSTRACT Increased fluctuating asymmetry, or random differences between right and left sides, has been associated with developmental stress or developmental instability. This study examines fluctuating asymmetry (FA) of mesio‐distal and bucco‐lingual dimensions of deciduous maxillary molars (m1, m2), and permanent maxillary premolars and molars (P3, P4, M1, M2) of 466 rhesus macaques (Macaca mulatta) born between 1950 and 2018 from Cayo Santiago (CS), Puerto Rico. All included individuals were of known age, sex, birth year, and matriline. We assess whether a secular trend occurs in FA over a 68‐year period, sex differences in FA, and whether environmental or management factors in the colony history resulted in decreased FA. Regression of FA on birth year tested for a secular trend in FA. A mixed‐model two‐way analysis of variance was used to test for the influence of food supplementation, tetanus vaccination and hurricane experience during dental development on FA. Differences across matrilines in response to the management or environmental factors were tested by ANOVA. There was no significant secular trend in FA. There was limited reduction of FA with implementation of the high protein diet, and limited support for the decreased FA associated with the implementation of tetanus vaccination. There is also limited difference in dental FA associated with exposure to a hurricane during dental development. Matrilineal differences in FA were observed for several teeth. The free‐ranging environment of Cayo Santiago is a complex environment, with many factors influencing the development of young rhesus macaques. While the introduction of a high protein diet or the implementation of a tetanus vaccination program may have improved individual health overall, there are likely other factors that may cause developmental stress and result in dental FA.
Francis, George, and Wang, Qian. History of Health at Cayo Santiago—An Investigation of Environmental and Genetic Influences on the Skeletal Remains of the Introduced Rhesus Macaque ( Macaca mulatta ) Colony. Retrieved from https://par.nsf.gov/biblio/10651623. American Journal of Primatology 87.1 Web. doi:10.1002/ajp.23722.
Francis, George, & Wang, Qian. History of Health at Cayo Santiago—An Investigation of Environmental and Genetic Influences on the Skeletal Remains of the Introduced Rhesus Macaque ( Macaca mulatta ) Colony. American Journal of Primatology, 87 (1). Retrieved from https://par.nsf.gov/biblio/10651623. https://doi.org/10.1002/ajp.23722
Francis, George, and Wang, Qian.
"History of Health at Cayo Santiago—An Investigation of Environmental and Genetic Influences on the Skeletal Remains of the Introduced Rhesus Macaque ( Macaca mulatta ) Colony". American Journal of Primatology 87 (1). Country unknown/Code not available: Wiley. https://doi.org/10.1002/ajp.23722.https://par.nsf.gov/biblio/10651623.
@article{osti_10651623,
place = {Country unknown/Code not available},
title = {History of Health at Cayo Santiago—An Investigation of Environmental and Genetic Influences on the Skeletal Remains of the Introduced Rhesus Macaque ( Macaca mulatta ) Colony},
url = {https://par.nsf.gov/biblio/10651623},
DOI = {10.1002/ajp.23722},
abstractNote = {ABSTRACT The Cayo Santiago rhesus macaque colony is a renowned primate population that has experienced significant natural and anthropogenic ecological variation in their 85‐year history. Demographic and familial information is also tracked and collated for the majority of monkeys. Thus, the health history of rhesus macaques at Cayo Santiago should reflect the impacts of both environmental and genetic factors. In this study, we utilized a sample of skeletal remains comprised of 2787 individuals (1571 females, 1091 males), born between 1938 and 2017 from the derived skeletal collection of the primate colony to assess variation in survivorship, pathology, bone mineral density (BMD), and dental eruption status, in the context of hurricane impacts, nutritional fluctuations, and matriline genealogy. Results demonstrated that rhesus macaques at Cayo Santiago exhibit a range of skeletal pathologies that encompass biomedical and archaeological significance, multiple etiologies, severities, locations, and types, in addition to a secular trend of declining BMD that is hypothesized to reflect decreasing physical activity levels under increasing population densities. Specifically, hurricane impacts were found to increase the rate of systemic disease, decrease BMD in young adults, and delay eruption of the primary dentition. Certain matrilines exhibited heightened levels of systemic disease at early ages while others exhibited greater rates of congenital disease. Early‐life adversity, through the experience of major hurricanes, may enhance inflammatory pathways, heightening the risk of disease and accelerating the aging process leading to reduced BMD. Such impacts may underly greater levels of observed infection post‐hurricane through intensification of pathogen transmission and disease rates brought on by hurricane‐adaptive social strategies that favor closer proximity. Familial susceptibility to disease indicates heritable host genetic factors are likely influencing disease patterning in the population. A cluster of congenital diseases may most convincingly illustrate this, or alternatively reflects low levels of genetic diversity in the population.},
journal = {American Journal of Primatology},
volume = {87},
number = {1},
publisher = {Wiley},
author = {Francis, George and Wang, Qian},
}
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