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Turbulent boundary layers are dominated by large-scale motions (LSMs) of streamwise momentum surplus and deficit that contribute significantly to the statistics of the flow. In particular, the high-momentum LSMs residing in the outer region of the boundary layer have the potential to re-energize the flow and delay separation if brought closer to the wall. This work explores the effect of selectively manipulating LSMs in a moderate Reynolds number turbulent boundary layer for separation delay via well-resolved large-eddy simulations. Toward that goal, a model predictive control scheme is developed based on a reduced-order model of the flow that directs LSMs of interest closer to the wall in an optimal way via a body force-induced downwash. The performance improvement achieved by targeting LSMs for separation delay, compared to a naive actuation scheme that does not account for the presence of LSMs, is demonstrated.more » « less