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Abstract The superior accuracy isogeometric analysis (IGA) brought to computations in fluid and solid mechanics has been yielding higher fidelity in computational aerodynamics. The increased accuracy we achieve with the IGA is in the flow solution, in representing the problem geometry, and, when we use the IGA basis functions also in time in a space–time (ST) framework, in representing the motion of solid surfaces. It is of course as part of a set of methods that the IGA has been very effective in computational aerodynamics, including complex-geometry aerodynamics. The set of methods we have been using can be categorized into those that serve as a core method, those that increase the accuracy, and those that widen the application range. The core methods are the residual-based variational multiscale (VMS), ST-VMS and arbitrary Lagrangian–Eulerian VMS methods. The IGA and ST-IGA are examples of the methods that increase the accuracy. The complex-geometry IGA mesh generation method is an example of the methods that widen the application range. The ST Topology Change method is another example of that. We provide an overview of these methods for IGA-based computational aerodynamics and present examples of the computations performed. In computational flow analysis with moving solid surfaces and contact between the solid surfaces, it is a challenge to represent the boundary layers with an accuracy attributed to moving-mesh methods and represent the contact without leaving a mesh protection gap. 

The challenges encountered in computational analysis of wind turbines and turbomachinery include turbulent rotational flows, complex geometries, moving boundaries and interfaces, such as the rotor motion, and the fluid-structure interaction (FSI), such as the FSI between the wind turbine blade and the air. The Arbitrary Lagrangian-Eulerian (ALE) and Space-Time (ST) Variational Multiscale (VMS) methods and isogeometric discretization have been effective in addressing these challenges. The ALE-VMS and ST-VMS serve as core computational methods. They are supplemented with special methods like the Slip Interface (SI) method and ST Isogeometric Analysis with NURBS basis functions in time. We describe the core and special methods and present, as examples of challenging computations performed, computational analysis of horizontaland vertical-axis wind turbines and flow-driven This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.string dynamics in pumps. 

Computational cardiovascular flow analysis can provide valuable information to medical doctors in a wide range of patientspecific cases, including cerebral aneurysms, aortas and heart valves. The computational challenges faced in this class of flow analyses also have a wide range. They include unsteady flows, complex cardiovascular geometries, moving boundaries and interfaces, such as the motion of the heart valve leaflets, contact between moving solid surfaces, such as the contact between the leaflets, and the fluid–structure interaction between the blood and the cardiovascular structure. Many of these challenges have been or are being addressed by the Space–Time Variational Multiscale (ST-VMS) method, Arbitrary Lagrangian–Eulerian VMS (ALE-VMS) method, and the VMS-based Immersogeometric Analysis (IMGA-VMS), which serve as the core computational methods, and the special methods used in combination with them. We provide an overview of the core and special methods and present examples of challenging computations carried out with these methods, including aorta and heart valve flow analyses. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.