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  1. Introduction: The American Cancer Society predicted that approximately 96,480 people will be diagnosed with melanoma skin cancer this year, and 7,230 of them will die [1]. Minimally-invasive alternatives for melanoma treatment are a clinical need, and a continued unmet need exists for combinatorial therapies with limited toxicity and/or resistance profiles. Photothermal therapy (PTT) can be used as a non-invasive treatment by delivering targeted nanoparticles and a laser source (typically in the near-infrared range) to the tumor site. We propose to use a biodegradable nanoparticle platform based in polymers to reduce the toxic risks. Our goal is to evaluate the cellular lethality of nanoparticles on melanoma cells as a response to dosimetry using an in vitro model. 
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