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Akuzipik (Yupigestun/Yupik/St. Lawrence Island Yupik/Siberian Yupik/Chaplinski Yupik) is an endangered language belonging to the Yupik branch of the Inuit-Yupik-Unangan language family. It is currently spoken by 800-900 people in the Bering Strait region, mainly on St. Lawrence Island, Alaska (St. Lawrence Island Yupik), and on the coast of the Chukotka Peninsula, in Russia (Chaplinski Yupik) (de Reuse 1994; Schwartz et al. 2019). The linguistic differences between these two varieties seem to be minor and not affect mutual intelligibility (Krauss 1975). The language has been undergoing a rapid generational shift, beginning in the 1950s in Russia and in the 1990s in Alaska (Schwartz et al. 2019).

Akuzipik (Yupigestun/Yupik/St. Lawrence Island Yupik/Siberian Yupik/Chaplinski Yupik) is an endangered language belonging to the Yupik branch of the Inuit-Yupik-Unangan language family. It is currently spoken by 800-900 people in the Bering Strait region, mainly on St. Lawrence Island, Alaska (St. Lawrence Island Yupik), and on the coast of the Chukotka Peninsula, in Russia (Chaplinski Yupik) (de Reuse 1994; Schwartz et al. 2019). The linguistic differences between these two varieties seem to be minor and not affect mutual intelligibility (Krauss 1975). The language has been undergoing a rapid generational shift, beginning in the 1950s in Russia and in the 1990s in Alaska (Schwartz et al. 2019).

St. Lawrence Island Yupik (ISO 639-3: ess) is an endangered polysynthetic language in the Inuit-Yupik language family indigenous to Alaska and Chukotka. This work presents a step-by-step pipeline for the digitization of written texts, and the first publicly available digital corpus for St. Lawrence Island Yupik, created using that pipeline. This corpus has great potential for future linguistic inquiry and research in NLP. It was also developed for use in Yupik language education and revitalization, with a primary goal of enabling easy access to Yupik texts by educators and by members of the Yupik community. A secondary goal is to support development of language technology such as spell-checkers, text-completion systems, interactive e-books, and language learning apps for use by the Yupik community.

Diarylethenes (DAEs) represent an important class of photochromes with notable characteristics, like thermally irreversible photoisomerization and high fatigue resistance. Structural diversification of the DAE scaffold has enabled further refinement of photochromic properties and realization of new applications, ranging from advanced materials to tools for studying biological systems. In particular, methods for synthesizing non-symmetric DAE scaffolds, which are typically more challenging to synthesize than their symmetric counterparts, have grown over the past 20 years. These developments are surveyed in this review, with discussion of how access to these compounds has contributed to the improvement of photochromic properties and paved the way for exploring new applications of DAEs. First, non-symmetric DAE structures are classified and their uses and applications are overviewed. Subsequent sections discuss the main strategies that have been used to access non-symmetric DAEs with examples illustrating the impact of non-symmetric DAEs in the growing field of light-controlled molecular systems.

St. Lawrence Island Yupik is an endangered polysynthetic language of the Bering Strait region. While conducting linguistic fieldwork between 2016 and 2019, we observed substantial support within the Yupik community for language revitalization and for resource development to support Yupik education. To that end, Chen & Schwartz (2018) implemented a finite-state morphological analyzer as a critical enabling technology for use in Yupik language education and technology. Chen & Schwartz (2018) reported a morphological analysis coverage rate of approximately 75% on a dataset of 60K Yupik tokens, leaving considerable room for improvement. In this work, we present a re-implementation of the Chen & Schwartz (2018) finite-state morphological analyzer for St. Lawrence Island Yupik that incorporates new linguistic insights; in particular, in this implementation we make use of the Paradigm Function Morphology (PFM) theory of morphology. We evaluate this new PFM-based morphological analyzer, and demonstrate that it consistently outperforms the existing analyzer of Chen & Schwartz (2018) with respect to accuracy and coverage rate across multiple datasets.

Recent genome-wide studies have begun to identify gene variants, expression profiles, and regulators associated with neuroticism, anxiety disorders, and depression. We conducted a set of experimental cell culture studies of gene regulation by micro RNAs (miRNAs), based on genome-wide transcriptome, proteome, and miRNA expression data from twentypostmortemsamples of lateral amygdala from donors with known neuroticism scores. Using Ingenuity Pathway Analysis and TargetScan, we identified a list of mRNA–protein–miRNA sets whose expression patterns were consistent with miRNA-based translational repression, as a function of trait anxiety. Here, we focused on one gene from that list, which is of particular translational significance in Psychiatry: synaptic vesicle glycoprotein 2A (SV2A) is the binding site of the anticonvulsant drug levetiracetam ((S)-α-Ethyl-2-oxo-1-pyrrolidineacetamide), which has shown promise in anxiety disorder treatments. We confirmed thatSV2Ais associated with neuroticism or anxiety using an original GWAS of a community cohort (N = 1,706), and cross-referencing a published GWAS of multiple cohorts (Ns ranging from 340,569 to 390,278).Postmortemamygdala expression profiling implicated three putative regulatory miRNAs to targetSV2A: miR-133a, miR-138, and miR-218. Moving from association to experimental causal testing in cell culture, we used a luciferase assay to demonstrate that miR-133a and miR-218, but not miR-138, significantly decreased relative luciferase activity from theSV2Adual-luciferasemore »construct. In human neuroblastoma cells, transfection with miR-133a and miR-218 reduced both endogenousSV2AmRNA and protein levels, confirming miRNA targeting of theSV2Agene. This study illustrates the utility of combiningpostmortemgene expression data with GWAS to guide experimental cell culture assays examining gene regulatory mechanisms that may contribute to complex human traits. Identifying specific molecular mechanisms of gene regulation may be useful for future clinical applications in anxiety disorders or other forms of psychopathology.

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St. Lawrence Island Yupik is an endangered language of the Bering Strait region. In this paper, we describe our work on Yupik jointly leveraging computational morphology and linguistic fieldwork, outlining the multilayer virtuous cycle that we continue to refine in our work to document and build tools for the language. After developing a preliminary morphological analyzer from an existing pedagogical grammar of Yupik, we used it to help analyze new word forms gathered through fieldwork. While in the eld, we augmented the analyzer to include in- sights into the lexicon, phonology, and morphology of the language as they were gained during elicitation sessions and subsequent data analysis. The analyzer and other tools we have developed are improved by a corpus that continues to grow through our digitization and documentation efforts, and the computational tools in turn allow us to improve and speed those same efforts. Through this process, we have successfully identified previously undescribed lexical, morphological, and phonological processes in Yupik while simultaneously increasing the coverage of the morphological analyzer. Given the polysynthetic nature of Yupik, a high-coverage morphological analyzer is a necessary prerequisite for the development of other high-level computational tools that have been requested by the Yupik community.