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Internet of Things (IoT) cyber threats, exemplified by jackware and crypto mining, underscore the vulnerability of IoT devices. Due to the multi-step nature of many attacks, early detection is vital for a swift response and preventing malware propagation. However, accurately detecting early-stage attacks is challenging, as attackers employ stealthy, zero-day, or adversarial machine learning to evade detection. To enhance security, we propose ARIoTEDef, an Adversarially Robust IoT Early Defense system, which identifies early-stage infections and evolves autonomously. It models multi-stage attacks based on a cyber kill chain and maintains stage-specific detectors. When anomalies in the later action stage emerge, the system retroactively analyzes event logs using an attention-based sequence-to-sequence model to identify early infections. Then, the infection detector is updated with information about the identified infections. We have evaluated ARIoTEDef against multi-stage attacks, such as the Mirai botnet. Results show that the infection detector’s average F1 score increases from 0.31 to 0.87 after one evolution round. We have also conducted an extensive analysis of ARIoTEDef against adversarial evasion attacks. Our results show that ARIoTEDef is robust and benefits from multiple rounds of evolution. 

Bio-inspired pinecone-like bioactive glasses consisting of ordered thin-layers separated by consistent cavities were synthesized using a sol–gel process. The short diameter of the as-produced particles was as short as 161 nm, and the surface area was as high as 280 m 2 g −1 . The pore volume, ranging from ∼0.74 cm 3 g −1 to ∼0.67 cm 3 g −1 , could be modulated by the aqueous ammonia concentration. The surface was further tailored for positive charges by amino grafting. The as-produced nanoparticles could successfully enter cells via endocytosis. The microRNA delivery of the bioactive glass particles was further investigated by fluorescence microscopy and flow cytometry, indicating a loading efficiency and transfection efficiency greater than 90%. The potential of such particles as drug carriers was also studied. CCK8, live–dead cell staining and PI/annexinV double staining analyses confirmed that the bioactive glass particles loaded with antitumour doxorubicin (DOX) significantly accelerated the apoptosis of tumour cells. These bio-inspired bioactive glasses are promising as novel vectors for drug and microRNA delivery with high efficiency.