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ObjectiveAs opposed to postconcussion physical activity, the potential influence of cognitive activity on concussion recovery is not well characterised. This study evaluated the intensity and duration of daily cognitive activity reported by adolescents following concussion and examined the associations between these daily cognitive activities and postconcussion symptom duration. MethodsThis study prospectively enrolled adolescents aged 11–17 years with a physician-confirmed concussion diagnosis within 72 hours of injury from the emergency department and affiliated concussion clinics. Participants were followed daily until symptom resolution or a maximum of 45 days postinjury to record their daily cognitive activity (intensity and duration) and postconcussion symptom scores. ResultsParticipants (n=83) sustained their concussion mostly during sports (84%), had a mean age of 14.2 years, and were primarily male (65%) and white (72%). Participants reported an average of 191 (SD=148), 166 (SD=151) and 38 (SD=61) minutes of low-intensity, moderate-intensity and high-intensity daily cognitive activity postconcussion while still being symptomatic. Every 10 standardised minutes per hour increase in moderate-intensity or high-intensity cognitive activities postconcussion was associated with a 22% greater rate of symptom resolution (adjusted hazard ratio (aHR) 1.22, 95% CI 1.01 to 1.47). Additionally, each extra day’s delay in returning to school postconcussion was associated with an 8% lower rate of symptom resolution (aHR 0.92, 95% CI 0.85 to 0.99). ConclusionIn adolescents with concussion, more moderate-high intensity cognitive activity is associated with faster symptom resolution, and a delayed return to school is associated with slower symptom resolution. However, these relationships may be bidirectional and do not necessarily imply causality. Randomised controlled trials are needed to determine if exposure to early cognitive activity can promote concussion recovery in adolescents. 

As collective cell migration is essential in biological processes spanning development, healing, and cancer progression, methods to externally program cell migration are of great value. However, problems can arise if the external commands compete with strong, preexisting collective behaviors in the tissue or system. We investigate this problem by applying a potent external migratory cue—electrical stimulation and electrotaxis—to primary mouse skin monolayers where we can tune cell–cell adhesion strength to modulate endogenous collectivity. Monolayers with high cell–cell adhesion showed strong natural coordination and resisted electrotactic control, with this conflict actively damaging the leading edge of the tissue. However, reducing preexisting coordination in the tissue by specifically inhibiting E-cadherin–dependent cell–cell adhesion, either by disrupting the formation of cell–cell junctions with E-cadherin–specific antibodies or rapidly dismantling E-cadherin junctions with calcium chelators, significantly improved controllability. Finally, we applied this paradigm of weakening existing coordination to improve control and demonstrate accelerated wound closure in vitro. These results are in keeping with those from diverse, noncellular systems and confirm that endogenous collectivity should be considered as a key quantitative design variable when optimizing external control of collective migration. 

ABSTRACT We report Keck–NIRSPEC observations of the Brackett α 4.05 μm recombination line across the two candidate embedded super star clusters (SSCs) in NGC 1569. These SSCs power a bright H ii region and have been previously detected as radio and mid-infrared sources. Supplemented with high-resolution VLA mapping of the radio continuum along with IRTF–TEXES spectroscopy of the [S iv] 10.5 μm line, the Brackett α data provide new insight into the dynamical state of gas ionized by these forming massive clusters. Near-infrared sources detected in 2 μm images from the slit-viewing Camera are matched with Gaia sources to obtain accurate celestial coordinates and slit positions to within ∼0$${_{.}^{\prime\prime}}$$1. Br α is detected as a strong emission peak powered by the less luminous infrared source, MIR1 (LIR ∼ 2 × 107 $$\rm L_\odot$$). The second candidate SSC MIR2 is more luminous (LIR ≳ 4 × 108 $$\rm L_\odot$$) but exhibits weak radio continuum and Br α emission, suggesting the ionized gas is extremely dense (ne ≳ 105 cm−3), corresponding to hypercompact H ii regions around newborn massive stars. The Br α and [S iv] lines across the region are both remarkably symmetric and extremely narrow, with observed line widths Δv ≃ 40 $$\rm km\, s^{-1}$$, full width at half-maximum. This result is the first clear evidence that feedback from NGC 1569’s youngest giant clusters is currently incapable of rapid gas dispersal, consistent with the emerging theoretical paradigm in the formation of giant star clusters. 

ABSTRACT We observed the Brackett α emission line (4.05 μm) within the nuclear starburst of NGC 253 to measure the kinematics of ionized gas, and distinguish motions driven by star formation feedback from gravitational motions induced by the central mass structure. Using NIRSPEC on Keck II, we obtained 30 spectra through a $$0^{\prime \prime }_{.}5$$ slit stepped across the central ∼5 arcsec × 25 arcsec (85 × 425 pc) region to produce a spectral cube. The Br α emission resolves into four nuclear sources: S1 at the infrared core (IRC), N1 at the radio core, and the fainter sources N2 and N3 in the northeast. The line profile is characterized by a primary component with Δvprimary ∼90–130 $$\rm km\, s^{-1}$$ (full width at half-maximum) on top of a broad blue 2wing with Δvbroad ∼300–350 $$\rm km\, s^{-1}$$, and an additional redshifted narrow component in the west. The velocity field generated from our cube reveals several distinct patterns. A mean NE–SW velocity gradient of +10 $$\rm km\, s^{-1}$$ arcsec−1 along the major axis traces the solid-body rotation curve of the nuclear disc. At the radio core, isovelocity contours become S-shaped, indicating the presence of secondary nuclear bar of total extent ∼5 arcsec (90 pc). The symmetry of the bar places the galactic centre, and potential supermassive black hole, near the radio peak rather than the IRC. A third kinematic substructure is formed by blueshifted gas near the IRC. This feature likely traces a ∼100–250 $$\rm km\, s^{-1}$$ starburst-driven outflow, potentially linking the IRC to the galactic wind observed on kpc scales. 

Abstract Helmet continuous positive applied pressure is a form of noninvasive ventilation (NIV) that has been used to provide respiratory support to COVID-19 patients. Helmet NIV is low-cost, readily available, provides viral filters between the patient and clinician, and may reduce the need for invasive ventilation. Its widespread adoption has been limited, however, by the lack of a respiratory monitoring system needed to address known safety vulnerabilities and to monitor patients. To address these safety and clinical needs, we developed an inexpensive respiratory monitoring system based on readily available components suitable for local manufacture. Open-source design and manufacturing documents are provided. The monitoring system comprises flow, pressure, and CO2 sensors on the expiratory path of the helmet circuit and a central remote station to monitor up to 20 patients. The system is validated in bench tests, in human-subject tests on healthy volunteers, and in experiments that compare respiratory features obtained at the expiratory path to simultaneous ground-truth measurements from proximal sensors. Measurements of flow and pressure at the expiratory path are shown to deviate at high flow rates, and the tidal volumes reported via the expiratory path are systematically underestimated. Helmet monitoring systems exhibit high-flow rate, nonlinear effects from flow and helmet dynamics. These deviations are found to be within a reasonable margin and should, in principle, allow for calibration, correction, and deployment of clinically accurate derived quantities.