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Honey bee colony deaths are associated with viruses, which frequently do not cause morphological symptoms in adult bees. To assess the impact of these inapparent infections, we measured flight performance as a proxy for honey bee health. We hypothesized that deformed wing virus (DWV) and/or sacbrood virus (SBV) would reduce flight performance and that co-infections would have compounding, negative impacts. We identified virus-specific effects; bees with DWV flew shorter distances at slower speeds, whereas bees with SBV flew greater distances at higher speeds. Bees with high virus loads expressed more heat shock protein 90, and SBV-infected bees expressed more octopamine ß-2 receptor (Oß-2R). Oß-2R binds octopamine, a ‘fight or flight’ molecule, stimulating metabolic activity, neuromuscular transmission, and movement. To examine relationships between virus infection, octopamine, and flight, we compared the flight performance of DWV-infected bees with octopamine treatment and demonstrated that octopamine negated DWV associated flight impairment. These findings have organismal, colony-, and ecosystem-level implications. 

The formation of a series of isostructural three-component co-crystals between 1,2,4,5-tetrachloro-3-iodobenzene and each of three isosteric bipyridines is reported. 

The MicroBooNE experiment is an 85 tonne active mass liquid argon time projection chamber neutrino detector exposed to the on-axis Booster Neutrino Beam at Fermilab. One of MicroBooNE’s physics goals is the precise measurement of neutrino interactions on argon in the 1 GeV energy regime. Building on the capabilities of the MicroBooNE detector, this analysis identifies $K^{+}$mesons, a key signature for the study of strange particle production in neutrino interactions. This measurement is furthermore valuable for background estimation for future nucleon decay searches and for improved reconstruction and particle identification capabilities in experiments such as the Deep Underground Neutrino Experiment. In this Letter, we present the first-ever measurement of a flux-integrated cross section for charged-current muon neutrino induced $K^{+}$production on argon nuclei, determined to be $7.93\pm 3.22\left(\mathrm{stat}\right)\pm 2.83\left(\mathrm{syst}\right)\times {10}^{-42}{\mathrm{cm}}^2/\mathrm{nucleon}$based on an analysis of $6.88\times {10}^{20}$protons on target. This result was found to be consistent with model predictions from different neutrino event generators within the reported uncertainties. 

Abstract The existence of three distinct neutrino flavours,ν_e,ν_μandν_τ, is a central tenet of the Standard Model of particle physics^1,2. Quantum-mechanical interference can allow a neutrino of one initial flavour to be detected sometime later as a different flavour, a process called neutrino oscillation. Several anomalous observations inconsistent with this three-flavour picture have motivated the hypothesis that an additional neutrino state exists, which does not interact directly with matter, termed as ‘sterile’ neutrino,ν_s(refs. ^3–9). This includes anomalous observations from the Liquid Scintillator Neutrino Detector (LSND)³experiment and Mini-Booster Neutrino Experiment (MiniBooNE)^4,5, consistent withν_μ → ν_etransitions at a distance inconsistent with the three-neutrino picture. Here we use data obtained from the MicroBooNE liquid-argon time projection chamber¹⁰in two accelerator neutrino beams to exclude the single light sterile neutrino interpretation of the LSND and MiniBooNE anomalies at the 95% confidence level (CL). Moreover, we rule out a notable portion of the parameter space that could explain the gallium anomaly^6–8. This is one of the first measurements to use two accelerator neutrino beams to break a degeneracy betweenν_eappearance and disappearance, which would otherwise weaken the sensitivity to the sterile neutrino hypothesis. We find no evidence for eitherν_μ → ν_eflavour transitions orν_edisappearance that would indicate non-standard flavour oscillations. Our results indicate that previous anomalous observations consistent withν_μ → ν_etransitions cannot be explained by introducing a single sterile neutrino state.