Search for: All records

Abstract Transdisciplinary research is increasingly important for solving complex societal problems. Institutions aim to train graduate students to engage in transdisciplinary research. However, limited evidence exists regarding the process by which students learn transdisciplinary thinking. This qualitative study explored graduate students’ pathways of growth toward transdisciplinary thinking during one semester. The students were enrolled in a professional development course as part of a training grant. We examined artifacts from the course through multiple rounds of thematic coding. We used a grounded theory approach to gain insights into how graduate students navigate their journey toward transdisciplinary thinking. We propose a model of this journey. It traces students’ trajectories from prior experiences, through reflexive thinking about several crucial skills and dispositions, towards a transdisciplinary “prism” that transforms their thinking. We conclude that becoming a transdisciplinary researcher is not a matter of acquiring competencies, but a life-long process. Fostering this process may require fundamental reimagining of graduate education. 

Not AvChelation therapy has long been recognized for its success in treating heavy metal poisoning and iron overload disorders. Building on this foundation, drug repurposing of FDA-approved iron chelators for anticancer therapy has been extensively explored, alongside the development of novel agents such as the promising triapine. Current research increasingly targets the essential metals iron, copper, and zinc in oncology, with a focus on chelators that actively modulate the biochemical effects of these metals rather than functioning as ionophores. This review highlights recent advances in refining chelation strategies to enhance cytotoxic potency and tumor specificity, including approaches that tune metal redox activity, synergize with platinum(II)-based drugs, incorporate nanoparticulate delivery systems, leverage metal-driven immunostimulation, and combine with established or emerging therapies. By assessing the successes and limitations of recent studies and surveying relevant human clinical trials, we evaluate the feasibility of integrating chelation therapy into clinical oncology. Evidence suggests that chelation is most effective when combined with other treatment modalities, offering potential synergistic benefits in cancer management.ailable