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ABSTRACT This study investigates the morphological, thermal, mechanical, and bioactive properties of centrifugally spun fibrous composites made from poly(D,L‐lactide)/poly(3‐hydroxybutyrate) (PLA/PHB) blends with zinc oxide (ZnO) and hydroxyapatite (Hap) nanoparticles. A 75/25 PLA/PHB weight ratio was chosen to balance mechanical and thermal properties. The precursor solution viscosities ranged from 0.25 to 0.50 Pa s, increasing with nanoparticle incorporation probably due to polymer‐nanoparticle interactions. SEM revealed a uniform fibrous morphology, with diameters of 1.21 for PLA/PHB, 2.65 for PLA/ZnO/Hap, and 1.80 μm for PLA/PHB/ZnO/Hap. TGA showed two‐step degradation for PLA/PHB fibers, while PLA/PHB/ZnO/Hap degraded in a single step at 249°C, leaving a residue of 9.95%. DSC indicated partial miscibility, with cold crystallization at 85°C (enthalpy: 7.72 J/g), slightly modified by nanoparticle addition. PLA/PHB fibers achieved a Young's modulus of 24.96 ± 3.91 MPa, three times that of pure PLA, but adding ZnO and Hap reduced modulus and tensile strength to 6.03 and 0.29 MPa, retaining suitability for biomedical applications. PLA/PHB/ZnO/Hap fibers exhibited 90%Escherichia coligrowth inhibition and enhanced MC3T3‐E1 cell viability by 120% on day 7. These results highlight their potential for antimicrobial, biocompatible medical devices. 

Abstract This study focuses on the fabrication, characterization and anticancer properties of biocompatible and biodegradable composite nanofibers consisting of poly(vinyl alcohol) (PVA), oxymatrine (OM), and citric acid (CA) using a facile and high‐yield centrifugal spinning process known as Forcespinning. The effects of varying concentrations of OM and CA on fiber diameter and molecular cross‐linking are investigated. The morphological and thermo‐physical properties, as well as water absorption of the developed nanofiber‐based mats are characterized using microscopical analysis, energy dispersive X‐ray spectroscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, and thermogravimetric analysis. In vitro anticancer studies are conducted with HCT116 colorectal cancer cells. Results show a high yield of long fibers embedded with beads. Fiber average diameters range between 462 and 528 nm depending on OM concentration. The thermal analysis results show that the fibers are stable at room temperature. The anticancer study reveals that PVA nanofiber membrane with high concentrations of OM can suppress the proliferation of HCT116 colorectal cancer cells. The study provides a comprehensive investigation of OM embedded into nanosized PVA fibers and the prospective application of these membranes as a drug delivery system.