Search for: All records | NSF Public Access

Note: When clicking on a Digital Object Identifier (DOI) number, you will be taken to an external site maintained by the publisher. Some full text articles may not yet be available without a charge during the embargo (administrative interval).
What is a DOI Number?

Some links on this page may take you to non-federal websites. Their policies may differ from this site.

An orthologous gene coevolution network provides insight into eukaryotic cellular and genomic structure and function

https://doi.org/10.1126/sciadv.abn0105

Steenwyk, Jacob L. ; Phillips, Megan A. ; Yang, Feng ; Date, Swapneeta S. ; Graham, Todd R. ; Berman, Judith ; Hittinger, Chris Todd ; Rokas, Antonis ( May 2022 , Science Advances)

The budding yeast coevolution network captures cellular structure and function in the absence of functional data.
more » « less
Full Text Available
US 2020 General Official Raw Election Results Files

https://doi.org/10.7910/DVN/0GKBGT

Singer, Stephanie Frank ; Srungavarapu, Janaki Raghuram ; Graham, Todd ( January 2021 , Harvard Dataverse)

Official election results for each of the 50 states, the five major territories and the District of Columbia) for the 2020 General Election. Some files provide results at the precinct level; others have results as the county level (or equivalent for jurisdictions that do not report by county). Contests include all federal contests, most statewide and most state legislative contests. These are the original files from the boards of elections or, where the board of elections provided only pdf or html, the files contain data copied directly en masse from the original files.
more » « less
Modeling and Cost Benefit Analysis to Guide Deployment of POC Diagnostics for Non-typhoidal Salmonella Infections with Antimicrobial Resistance

https://doi.org/10.1038/s41598-019-47359-2

Manore, Carrie ; Graham, Todd ; Carr, Alexa ; Feryn, Alicia ; Jakhar, Shailja ; Mukundan, Harshini ; Highlander, Hannah Callender ( August 2019 , Scientific Reports)

Abstract
Invasive non-typhoidalSalmonella(NTS) is among the leading causes of blood stream infections in sub-Saharan Africa and other developing regions, especially among pediatric populations. Invasive NTS can be difficult to treat and have high case-fatality rates, in part due to emergence of strains resistant to broad-spectrum antibiotics. Furthermore, improper treatment contributes to increased antibiotic resistance and death. Point of care (POC) diagnostic tests that rapidly identify invasive NTS infection, and differentiate between resistant and non-resistant strains, may greatly improve patient outcomes and decrease resistance at the community level. Here we present for the first time a model for NTS dynamics in high risk populations that can analyze the potential advantages and disadvantages of four strategies involving POC diagnostic deployment, and the resulting impact on antimicrobial treatment for patients. Our analysis strongly supports the use of POC diagnostics coupled with targeted antibiotic use for patients upon arrival in the clinic for optimal patient and public health outcomes. We show that even the use of imperfect POC diagnostics can significantly reduce total costs and number of deaths, provided that the diagnostic gives results quickly enough that patients are likely to return or stay to receive targeted treatment.

more » « less