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Creators/Authors contains: "Guo, Cheng"

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  1. Abstract

    Multimodal integration combines information from different sources or modalities to gain a more comprehensive understanding of a phenomenon. The challenges in multi-omics data analysis lie in the complexity, high dimensionality, and heterogeneity of the data, which demands sophisticated computational tools and visualization methods for proper interpretation and visualization of multi-omics data. In this paper, we propose a novel method, termed Orthogonal Multimodality Integration and Clustering (OMIC), for analyzing CITE-seq. Our approach enables researchers to integrate multiple sources of information while accounting for the dependence among them. We demonstrate the effectiveness of our approach using CITE-seq data sets for cell clustering. Our results show that our approach outperforms existing methods in terms of accuracy, computational efficiency, and interpretability. We conclude that our proposed OMIC method provides a powerful tool for multimodal data analysis that greatly improves the feasibility and reliability of integrated data.

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    Free, publicly-accessible full text available December 1, 2025
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  4. We discuss three emerging applications of wavelength conversion: 1) hybrid amplification outside of EDFA band, based on a combination of two wavelength converters and an EDFA, 2) spatial-mode-selective wavelength conversion, and 3) generation of spatial-mode-entangled photon pairs. 
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  5. Abstract

    We propose the generation of 3D linear light bullets propagating in free space using a single passive nonlocal optical surface. The nonlocal nanophotonics can generate space–time coupling without any need for bulky pulse-shaping and spatial modulation techniques. Our approach provides simultaneous control of various properties of the light bullets, including the external properties such as the group velocity and the propagation distance, and internal degrees of freedom such as the spin angular momentum and the orbital angular momentum.

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  6. We discuss wavelength conversion of a selected signal spatial mode, which preserves its quantum state and does not disturb other signal spatial modes. We present the results for a lithium niobate waveguide and a few-mode-fiber. 
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    We describe OAM-compatible mode-selective frequency conversion in a few-mode fiber and experimentally demonstrate downconversion of various superpositions of signal modes LP11a and LP11b to the same LP11b mode with conversion efficiency differences <0.8 dB. 
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  8. Differentiation has widespread applications, particularly in image processing for edge detection. Significant advances have been made in using nanophotonic structures and metamaterials to perform such operations. In particular, a recent work demonstrated a topological differentiator in which the transfer function exhibited a topological charge, making the differentiation operation robust to variations in operating conditions. The demonstrated topological differentiator, however, operates in reflection mode at off-normal incidence and is difficult to integrate into compact imaging systems. In this work, we design a topological differentiator that operates isotropically in transmission mode at normal incidence. The device exhibits an optical transfer function with a symmetry-protected topological charge of±<#comment/>2and performs second-order differentiation. Our work points to the potential of harnessing topological concepts for optical computing applications.

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    Aiming at producing spatial-mode-entangled photon pairs in a few-mode fiber, we experimentally demonstrate generation of idler beam from a seed signal in a superposition of two fiber modes. For every signal mode superposition, we observe the indication of idler mode orthogonality to the signal mode. 
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    We present a scheme for spatial-mode-selective frequency conversion in a few-mode fiber and experimentally demonstrate upconversion of arbitrary superpositions of two signal modes from C-band to the fundamental mode in S-band with conversion efficiencies within 1 dB range of one another. 
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