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Our lab previously established that repeated exposure to a bitter diet can increase salivary protein (SP) expression, which corresponds to an increase in acceptance of the bitter stimulus. However, this work was exclusively in male rodents, here we examine sex differences. We found that there are no differences in SP expression (experiment 1) or quinine diet acceptance (experiment 2) across stage of estrous cycle. Yet, males and females differ in feeding behaviors, SP expression, and responses to a quinine diet (experiment 3). On a quinine diet, males accepted the diet much faster than females. Males displayed a compensatory increase in meal number as meal size and rate of feeding decreased with initial exposure to a quinine diet, whereas females decreased meal size and rate of feeding with no compensation in meal number. There were sex differences in SP expression at day 14 of quinine exposure but these were gone by day 24. Both sexes increased acceptance of quinine in a brief access taste test after the feeding trial concluded. These data suggest that males and females have different patterns of bitter diet acceptance, but extended exposure to quinine diet still results in altered bitter taste responding and changes in SP profiles in females.