Search for: All records

It is no secret that the retention of students majoring in Science, Technology, Engineering, and Mathematics (STEM) has presented itself to be a challenge across the country. The National Science Foundation (NSF) allots substantial funding annually towards this effort. Jackson State University’s (JSU) Students Understanding Chemistry Concepts to Enhance STEM Skills (SUCCESS) Program is one such effort funded by the NSF. While the JSU Department of Biology had over 900 majors in 2016, data suggested that less than 23% would graduate with a bachelor’s degree within six years of entry. According to data obtained, the first four chemistry courses, General Chemistry (I & II) and Organic Chemistry (I & II), were significant barriers to the educational success of many Biology majors. A review of the literature provides many examples of initiatives to improve student retention. A reoccurring theme found that the comprehensive understanding of the students’ experiences within a particular major is essential to determining how best to impact student retention in that department. Student focus groups were implemented to evaluate the perceptions of Biology majors enrolled in Chemistry classes who utilized the SUCCESS Program. The overall impression of students in the SUCCESS Program was that it was helpful and beneficial to their classroom success, increased their confidence to learn Chemistry, and improved their understanding of Chemistry concepts. The students often identified scheduling conflicts as a hindrance to their participation. They also felt that the program was needed to help most students pass their tests. 

Electrophilic fluorine-mediated dearomative spirocyclization has been developed to synthesize a range of fluoro-substituted spiro-isoxazoline ethers and lactones. The in vitro biological assays of synthesized compounds were probed for anti-viral activity against human cytomegalovirus (HCMV) and cytotoxicity against glioblastomas (GBM6) and triple negative breast cancer (MDA MB 231). Interestingly, compounds 4d and 4n showed significant activity against HCMV (IC 50 ∼ 10 μM), while 4l and 5f revealed the highest cytotoxicity with IC 50 = 36 to 80 μM. The synthetic efficacy and biological relevance offer an opportunity to further drug-discovery development of fluoro-spiro-isoxazolines as novel anti-viral and anti-cancer agents.