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Abstract Climate change poses significant threats to global agriculture, impacting food quantity, quality, and safety. The world is far from meeting crucial climate targets, prompting the exploration of alternative strategies such as stratospheric aerosol intervention (SAI) to reduce the impacts. This study investigates the potential impacts of SAI on rice and wheat production in India, a nation highly vulnerable to climate change given its substantial dependence on agriculture. We compare the results from the Assessing Responses and Impacts of Solar climate intervention on the Earth system with Stratospheric Aerosol Injection‐1.5°C (ARISE‐SAI‐1.5) experiment, which aims to keep global average surface air temperatures at 1.5°C above preindustrial in the Shared Socioeconomic Pathway 2‐4.5 (SSP2‐4.5) global warming scenario. Yield results show ARISE‐SAI‐1.5 leads to higher production for rainfed rice and wheat. We use 10 agroclimatic indices during the vegetative, reproductive, and ripening stages to evaluate these yield changes. ARISE‐SAI‐1.5 benefits rainfed wheat yields the most, compared to rice, due to its ability to prevent rising winter and spring temperatures while increasing wheat season precipitation. For rice, SSP2‐4.5 leads to many more warm extremes than the control period during all three growth stages and may cause a delay in the monsoon. ARISE‐SAI‐1.5 largely preserves monsoon rainfall, improving yields for rainfed rice in most regions. Even without the use of SAI, adaptation strategies such as adjusting planting dates could offer partial relief under SSP2‐4.5 if it is feasible to adjust established rice‐wheat cropping systems. 

Abstract Electromyogram (EMG)-controlled prosthetic hands have advanced significantly during the past two decades. However, most of the currently available prosthetic hands fail to replicate human hand functionality and controllability. To measure the emulation of the human hand by a prosthetic hand, it is important to evaluate the functional characteristics. Moreover, incorporating feedback from end users during clinical testing is crucial for the precise assessment of a prosthetic hand. The work reported in this manuscript unfolds the functional characteristics of an EMG-CoNtrolled PRosthetIC Hand called ENRICH. ENRICH is a real-time EMG controlled prosthetic hand that can grasp objects in 250.8$$ \pm $$1.1 ms, fulfilling the neuromuscular constraint of a human hand. ENRICH is evaluated in comparison to 26 laboratory prototypes and 10 commercial variants of prosthetic hands. The hand was evaluated in terms of size, weight, operation time, weight lifting capacity, finger joint range of motion, control strategy, degrees of freedom, grasp force, and clinical testing. The box and block test and pick and place test showed ENRICH’s functionality and controllability. The functional evaluation reveals that ENRICH has the potential to restore functionality to hand amputees, improving their quality of life. 

Biomolecular condensates are increasingly recognized as key regulators of chromatin organization, yet how their formation and properties arise from protein sequences remains incompletely understood. Cross-species comparisons can reveal both conserved functions and significant evolutionary differences. Here, we integrate in vitro reconstitution, molecular dynamics simulations, and cell-based assays to examine how Drosophila and human variants of Polyhomeotic (Ph)—a subunit of the PRC1 chromatin regulatory complex— drive condensate formation through their sterile alpha motif (SAM) oligomerization domains. We identify divergent interactions between SAM and the disordered linker connecting it to the rest of Ph. These interactions enhance oligomerization and modulate both the formation and properties of reconstituted condensates. Oligomerization influences condensate dynamics but minimally impacts condensate formation. Linker-SAM interactions also affect condensate formation in Drosophila and human cells and growth in Drosophila imaginal discs. Our findings show how evolutionary changes in disordered linkers can finetune condensate properties, providing insights into sequence-function relationships.