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A photonic resonator interferometric scattering microscope for label-free detection of nanometer-scale objects with digital precision in point-of-use environments

https://doi.org/10.1016/j.bios.2023.115197

Liu, Leyang ; Tibbs, Joseph ; Li, Nantao ; Bacon, Amanda ; Shepherd, Skye ; Lee, Hankeun ; Chauhan, Neha ; Demirci, Utkan ; Wang, Xing ; Cunningham, Brian T. ( May 2023 , Biosensors and Bioelectronics)

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Accelerated Digital Biodetection Using Magneto-plasmonic Nanoparticle-Coupled Photonic Resonator Absorption Microscopy

https://doi.org/10.1021/acsnano.1c08569

Che, Congnyu ; Xue, Ruiyang ; Li, Nantao ; Gupta, Prashant ; Wang, Xiaojing ; Zhao, Bin ; Singamaneni, Srikanth ; Nie, Shuming ; Cunningham, Brian T. ( February 2022 , ACS Nano)

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Overcoming the limitations of COVID-19 diagnostics with nanostructures, nucleic acid engineering, and additive manufacturing

https://doi.org/10.1016/j.cossms.2021.100966

Li, Nantao ; Zhao, Bin ; Stavins, Robert ; Peinetti, Ana Sol ; Chauhan, Neha ; Bashir, Rashid ; Cunningham, Brian T. ; King, William P. ; Lu, Yi ; Wang, Xing ; et al ( February 2022 , Current Opinion in Solid State and Materials Science)

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Label-Free Digital Detection of Intact Virions by Enhanced Scattering Microscopy

https://doi.org/10.1021/jacs.1c09579

Li, Nantao ; Wang, Xiaojing ; Tibbs, Joseph ; Che, Congnyu ; Peinetti, Ana Sol ; Zhao, Bin ; Liu, Leyang ; Barya, Priyash ; Cooper, Laura ; Rong, Lijun ; et al ( February 2022 , Journal of the American Chemical Society)

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Photonic resonator interferometric scattering microscopy

https://doi.org/10.1038/s41467-021-21999-3

Li, Nantao ; Canady, Taylor D. ; Huang, Qinglan ; Wang, Xing ; Fried, Glenn A. ; Cunningham, Brian T. ( March 2021 , Nature Communications)

Abstract
Interferometric scattering microscopy is increasingly employed in biomedical research owing to its extraordinary capability of detecting nano-objects individually through their intrinsic elastic scattering. To significantly improve the signal-to-noise ratio without increasing illumination intensity, we developed photonic resonator interferometric scattering microscopy (PRISM) in which a dielectric photonic crystal (PC) resonator is utilized as the sample substrate. The scattered light is amplified by the PC through resonant near-field enhancement, which then interferes with the <1% transmitted light to create a large intensity contrast. Importantly, the scattered photons assume the wavevectors delineated by PC’s photonic band structure, resulting in the ability to utilize a non-immersion objective without significant loss at illumination density as low as 25 W cm⁻². An analytical model of the scattering process is discussed, followed by demonstration of virus and protein detection. The results showcase the promise of nanophotonic surfaces in the development of resonance-enhanced interferometric microscopies.

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