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Candidate Dark Galaxy-2 (CDG-2) is a potential dark galaxy consisting of four globular clusters (GCs) in the Perseus cluster, first identified in D. Li et al. through a sophisticated statistical method. The method searched for overdensities of GCs from a Hubble Space Telescope (HST) survey targeting Perseus. Using the same HST images and new imaging data from the Euclid survey, we report the detection of extremely faint but significant diffuse emission around the four GCs of CDG-2. We thus have exceptionally strong evidence that CDG-2 is a galaxy. This is the first galaxy detected purely through its GC population. Under the conservative assumption that the four GCs make up the entire GC population, preliminary analysis shows that CDG-2 has a total luminosity of L_V,gal = 6.2 ± 3.0 × 10^6 L_⊙ and a minimum GC luminosity of L_V,GC = 1.03 ± 0.2 × 10^6 L_⊙. Our results indicate that CDG-2 is one of the faintest galaxies having associated GCs, while at least ∼16.6% of its light is contained in its GC population. This ratio is likely to be much higher (∼33%) if CDG-2 has a canonical GC luminosity function (GCLF). In addition, if the previously observed GC-to-halo mass relations apply to CDG-2, it would have a minimum dark matter halo mass fraction of 99.94% to 99.98%. If it has a canonical GCLF, then the dark matter halo mass fraction is ≳99.99%. Therefore, CDG-2 may be the most GC dominated galaxy and potentially one of the most dark matter dominated galaxies ever discovered. 

Elementary science education, particularly in the 4th and 5th grades, is essential for setting the foundation for lifelong science learning, fostering critical thinking, and preparing students for success in science, technology, engineering, and mathematics (STEM) fields. This stage is especially critical for students with disabilities, as achievement gaps between them and their peers emerge during elementary school. Despite this importance, little is known about how science is taught in elementary classrooms during these critical years, particularly for students with disabilities. To address this gap, we surveyed teachers from a nationally representative sample of U.S. schools to examine elementary science education, including instructional practices, allocation of time, and the inclusion and support of students with disabilities. Our findings reveal that limited instructional time is allocated to science, with significant variability across classrooms. The amount of time dedicated to science instruction was significantly influenced by external factors, such as whether science was a tested subject. Students with disabilities often face additional barriers, including being pulled out of science instruction for special education services, resulting in missed opportunities to engage in science. These findings highlight the need to address opportunity gaps in science instruction to ensure all students have meaningful access to quality science education. 

The endocannabinoidome (eCBome) is the expanded endocannabinoid system (ECS) and studies show that there is a link between this system and how it modulates alcohol induced neuroinflammation. Using conditional knockout (cKO) mice with selective deletion of cannabinoid type 2 receptors (CB2Rs) in dopamine neurons (DAT-Cnr2) and in microglia (Cx3Cr1-Cnr2), we investigated how CB2Rs modulate behavioral and neuroinflammation induced by alcohol. Behavioral tests including locomotor and wheel running activity, rotarod performance test, and alcohol preference tests were used to evaluate behavioral changes induced by alcohol. Using ELISA assay, we investigated the level of pro-inflammatory cytokines, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1α (IL-1α), and interleukin-1β (IL-1β) in the hippocampus of mice. The findings demonstrated that locomotor activity, wheel running, and rotarod performance activities were significantly affected by cell-type specific deletion of CB2Rs in dopamine neurons and microglia. The non-selective CB2R agonist, WIN 55,212-2, reduced alcohol preference in the wild type and cell-type specific CB2R cKO mice. In addition, the result showed that cell-type specific deletion of CB2Rsper seand administration of alcohol to CB2R cKO mice increased the expression of proinflammatory cytokines in the hippocampus. These findings suggest the involvement of CB2Rs in modulating behavioral and immune alterations induced by alcohol.