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Over the last decade, reform in science education has placed an emphasis on the science practices as a way to engage students in the process of science and improve scientific literacy. A critical component of developing scientific literacy is learning to apply quantitative reasoning to authentic scientific phenomena and problems. Students need practice moving fluidly (or fluently) between math and science to develop a habit of mind that encourages the application of quantitative reasoning to real-world scenarios. Here we present a student-facing model that challenges students to think across these two fields. The model brings together math and science with a goal to increase scientific literacy by engaging students in quantitative reasoning within the context of scientific questions and phenomena. In the classroom, the model serves to help students visualize the logical and necessary moves they make as they use quantitative reasoning to connect science practices with mathematical thinking. 

Abstract Although still in its early stages, the production and investigation of 3D magnetic nanostructures signify a major advancement in both fundamental research and practical applications, with immense potential for next‐generation technologies. Here, for the fabrication of the 3D nanostructures, an innovative approach selecting aS= 1/2 4,4′‐dicyano‐2,2′‐biphenylene‐fused tetrazolinyl radical is adopted, chemically stable and thermodynamically robust, allowing thin film processing and growth. Interdigitated gold‐silicon dioxide hybrid surfaces are used as substrates since gold and silicon dioxide are two technologically relevant materials. The ability to: (1) grow radical nanostructures are demonstrated that retain their magnetic properties, (2) adjust their morphology and size, (3) selectively remove nanostructures from specific substrate regions using distilled water, and (4) return substrates to their pristine condition, making them reusable after washing. This research not only aims to produce innovative 3D nanostructures but also strives to improve efficiency and minimize consumption, aligning with the principles of circular economy. This approach is particularly beneficial for expensive materials, such as gold, or patterned hybrid substrates that require complex fabrication techniques. 

Abstract BACKGROUNDLimited research has explored the effect of cardiovascular risk and amyloid interplay on cognitive decline in East Asians. METHODSVascular burden was quantified using Framingham's General Cardiovascular Risk Score (FRS) in 526 Korean Brain Aging Study (KBASE) participants. Cognitive differences in groups stratified by FRS and amyloid positivity were assessed at baseline and longitudinally. RESULTSBaseline analyses revealed that amyloid‐negative (Aβ–) cognitively normal (CN) individuals with high FRS had lower cognition compared to Aβ– CN individuals with low FRS (p < 0.0001). Longitudinally, amyloid pathology predominantly drove cognitive decline, while FRS alone had negligible effects on cognition in CN and mild cognitive impairment (MCI) groups. CONCLUSIONOur findings indicate that managing vascular risk may be crucial in preserving cognition in Aβ– individuals early on and before the clinical manifestation of dementia. Within the CN and MCI groups, irrespective of FRS status, amyloid‐positive individuals had worse cognitive performance than Aβ– individuals. HighlightsVascular risk significantly affects cognition in amyloid‐negative older Koreans.Amyloid‐negative CN older adults with high vascular risk had lower baseline cognition.Amyloid pathology drives cognitive decline in CN and MCI, regardless of vascular risk.The study underscores the impact of vascular health on the AD disease spectrum. 

Organoids are a simplified version of an organ produced in vitro in three dimensions. CLASS microscopy and Raman spectroscopy, two complementary label-free techniques, can be used for comprehensive non-destructive profiling of live organoids.