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Subteam Replacement: given a team of people em- bedded in a social network to complete a certain task, and a subset of members (i.e., subteam) in this team which have become unavailable, find another set of people who can perform the subteam’s role in the larger team. We conjecture that a good candidate subteam should have high skill and structural similarity with the replaced subteam while sharing a similar connection with the larger team as a whole. Based on this conjecture, we propose a novel graph kernel which evaluates the goodness of candidate subteams in this holistic way freely adjustable to the need of the situation. To tackle the significant computational difficulties, we equip our kernel with a fast approximation algorithm which (a) employs effective pruning strategies, (b) exploits the similarity between candidate team structures to reduce kernel computations, and (c) features a solid theoretical bound on the quality of the obtained solution. We extensively test our solution on both synthetic and real datasets to demonstrate its effectiveness and efficiency. Our proposed graph kernel outputs more human-agreeable recommendations compared to metrics used in previous work, and our algorithm consistently outperforms alternative choices by finding near- optimal solutions while scaling linearly with the size of the replaced subteam.