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Abstract The cluster of differentiation 36 (CD36) domain defines the characteristic ectodomain associated with class B scavenger receptor (SR-B) proteins. In bilaterians, SR-Bs play critical roles in diverse biological processes including innate immunity functions such as pathogen recognition and apoptotic cell clearance, as well as metabolic sensing associated with fatty acid uptake and cholesterol transport. Although previous studies suggest this protein family is ancient, SR-B diversity across Eukarya has not been robustly characterized. We analyzed SR-B homologs identified from the genomes and transcriptomes of 165 diverse eukaryotic species. The presence of highly conserved amino acid motifs across major eukaryotic supergroups supports the presence of a SR-B homolog in the last eukaryotic common ancestor. Our comparative analyses of SR-B protein structure identify the retention of a canonical asymmetric beta barrel tertiary structure within the CD36 ectodomain across Eukarya. We also identify multiple instances of independent lineage-specific sequence expansions in the apex region of the CD36 ectodomain—a region functionally associated with ligand-sensing. We hypothesize that a combination of both sequence expansion and structural variation in the CD36 apex region may reflect the evolution of SR-B ligand-sensing specificity between diverse eukaryotic clades. 

Pion photoproduction in the $\vec{\gamma }\vec{p}\to {\pi }^{0}p$reaction has been measured in the FROzen Spin Target (FROST) experiment at the Thomas Jefferson National Accelerator Facility. In this experiment, circularly polarized photons with energies up to 3.082 GeV impinged on a transversely polarized frozen-spin target. Final-state protons were detected in the Continuous Electron Beam Accelerator Facility (CEBAF) Large Acceptance Spectrometer. The polarization observables $T$and $F$have been extracted for $W$from 1445 to 2525 MeV, of which the energy range is much broader, and the precision is better than the existing measurements in higher $W$ranges. The data generally agree with predictions of present partial-wave analyses but also show marked differences for higher $W$ranges. By incorporating the present data into the databases, the Scattering Analysis Interactive Data (SAID) fits have been improved with relatively small ${\chi }^2$and significant changes in the parameters of the $\mathrm{\Delta }\left(1910\right)1/2^{+}$and $N\left(2190\right)7/2^{-}$have been found with the JüBo model. 

Extracting accurate results from neutrino oscillation and cross section experiments requires accurate simulation of the neutrino-nucleus interaction. The rescattering of outgoing hadrons (final state interactions) by the rest of the nucleus is an important component of these interactions. We present a new measurement of proton transparency (defined as the fraction of outgoing protons that emerge without significant rescattering) using electron-nucleus scattering data recorded by the CLAS detector at Jefferson Laboratory on helium, carbon, and iron targets. This analysis uses a new data-driven method to extract the transparency. It defines transparency as the ratio of electron-scattering events with a detected proton to quasi-elastic electron-scattering events where a proton should have been knocked out. Our results are consistent with previous measurements that determined the transparency from the ratio of measured events to theoretically predicted events. We find that the GENIE event generator, which is widely used by oscillation experiments to simulate neutrino-nucleus interactions, needs to better describe both the nuclear ground state and proton rescattering in order to reproduce our measured transparency ratios, especially at lower proton momenta. 

Measurements of beam single-spin asymmetries in semi-inclusive deep-inelastic electron scattering (SIDIS) with positively charged kaons off protons have been performed with 10.6 and 10.2 GeV incident electron beams using the CLAS12 spectrometer at Jefferson Lab. We report an analysis of the electroproduction of positively charged kaons over a large kinematic range of fractional energy, Bjorken $x$, transverse momentum, and photon virtualities $Q^2$ranging from 1 ${\mathrm{GeV}}^2$up to 6 ${\mathrm{GeV}}^2$. This is the first published multidimensionally binned CLAS12 measurement of a kaon SIDIS single-spin asymmetry in the valence quark regime. The data provide constraints on the structure function ratio $F_{LU}^{sin\varphi }/F_{UU}$, where $F_{LU}^{sin\varphi }$is a quantity with a leading twist of twist-3 that can reveal novel aspects of the quark-gluon correlations within the nucleon. The impact of the data on understanding the underlying reaction mechanisms and their kinematic variation is explored using theoretical models for the different contributing twist-3 parton-distribution functions (PDFs) and fragmentation functions (FFs). 

We present the first threefold differential measurement for neutral-pion multiplicity ratios produced in semi-inclusive deep-inelastic electron scattering on carbon, iron, and lead nuclei normalized to deuterium from CLAS at Jefferson Lab. We found that the neutral-pion multiplicity ratio is maximally suppressed for the leading hadrons (energy fraction $z\to$1), suppression varying from 25% in carbon up to 75% in lead. An enhancement of the multiplicity ratio at low $z$and high $p_T^2$is observed, suggesting an interconnection between these two variables. This behavior is qualitatively similar to the previous twofold differential measurement of charged pions by the HERMES Collaboration and, recently, by CLAS Collaboration. The largest enhancement was observed at high $p_T^2$for heavier nuclei, namely, iron and lead, while the smallest enhancement was observed for the lightest nucleus, carbon. This behavior suggests a competition between partonic multiple scattering, which causes enhancement, and hadronic inelastic scattering, which causes suppression. 

Measurements of the polarization observables $\mathrm{\Sigma },\mathbf{P},\mathbf{T},{\mathbf{O}}_{\mathbf{x}},{\mathbf{O}}_{\mathbf{z}}$for the reaction $\vec{\gamma }p\to K_S^0{\mathrm{\Sigma }}^{+}$using a linearly polarized photon beam of energy 1.1 to 2.1 GeV are reported. The measured data provide information on a channel that has not been studied extensively, but is required for a full coupled-channel analysis in the nucleon resonance region. Observables have been simultaneously extracted using likelihood sampling with a Markov-Chain Monte Carlo process. Angular distributions in bins of photon energy $E_{\gamma }$are produced for each polarization observable. $\mathbf{T},{\mathbf{O}}_{\mathbf{x}}$, and ${\mathbf{O}}_{\mathbf{z}}$are first time measurements of these observables in this reaction. The extraction of $\mathrm{\Sigma }$extends the energy range beyond a previous measurement. The measurement of $\mathbf{P}$, the recoil polarization, is consistent with previous measurements. The measured data are shown to be significant enough to affect the estimation of the nucleon resonance parameters when fitted within a coupled-channels model. Published by the American Physical Society2025