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Ising machines have recently been attracting attention due to their apparent ability to solve5 difficult combinatorial problems using analog operational principles. Oscillator Ising Machines6 (OIM) are especially attractive because they can be implemented easily as integrated circuits (ICs)7 in standard CMOS electronics. We explore the performance of OIM for decoding noisy Multi-User8 MIMO signals, a problem of considerable interest in modern telecommunications. Our results9 indicate that OIM-based decoding achieves error rates almost as good as the optimal Maximum10 Likelihood method, over a wide range of practical signal-to-noise (SNR) values. At high SNR11 values, OIM achieves ~20x fewer errors than LMMSE, a decoding method used widely in industry12 today. We also investigate the influence of parameter precision on decoding performance, finding13 that using 6 or more bits of precision largely retains OIM’s advantages across all SNR values. We14 estimate that straightforward CMOS OIM implementations can easily solve MU-MIMO decoding15 problems in under 10ns, more than 100x faster than current industrial requirements. We conclude16 that oscillator Ising machines can be effective for real-world applications, possibly serving as an17 important enabler for future telecommunication standards. Our results and data provide guidance18 for designing hardware OIM prototypes specialized for MU-MIMO decoding.