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The last years have witnessed remarkable advances in our understanding of the emergence and consequences of topological constraints in biological and soft matter. Examples are abundant in relation to (bio)polymeric systems and range from the characterization of knots in single polymers and proteins to that of whole chromosomes and polymer melts. At the same time, considerable advances have been made in the description of the interplay between topological and physical properties in complex fluids, with the development of techniques that now allow researchers to control the formation of and interaction between defects in diverse classes of liquid crystals. Thanks to technological progress and the integration of experiments with increasingly sophisticated numerical simulations, topological biological and soft matter is a vibrant area of research attracting scientists from a broad range of disciplines. However, owing to the high degree of specialization of modern science, many results have remained confined to their own particular fields, with different jargon making it difficult for researchers to share ideas and work together towards a comprehensive view of the diverse phenomena at play. Compelled by these motivations, here we present a comprehensive overview of topological effects in systems ranging from DNA and genome organization to entangled proteins, polymeric materials, liquid crystals, and theoretical physics, with the intention of reducing the barriers between different fields of soft matter and biophysics. Particular care has been taken in providing a coherent formal introduction to the topological properties of polymers and of continuum materials and in highlighting the underlying common aspects concerning the emergence, characterization, and effects of topological objects in different systems. The second half of the review is dedicated to the presentation of the latest results in selected problems, specifically, the effects of topological constraints on the viscoelastic properties of polymeric materials; their relation with genome organization; a discussion on the emergence and possible effects of knots and other entanglements in proteins; the emergence and effects of topological defects and solitons in complex fluids. This review is dedicated to the memory of Marek Cieplak. 

Abstract We outline the “dark siren” galaxy catalog method for cosmological inference using gravitational wave (GW) standard sirens, clarifying some common misconceptions in the implementation of this method. When a confident transient electromagnetic counterpart to a GW event is unavailable, the identification of a unique host galaxy is in general challenging. Instead, as originally proposed by Schutz, one can consult a galaxy catalog and implement a dark siren statistical approach incorporating all potential host galaxies within the localization volume. Trott & Huterer recently claimed that this approach results in a biased estimate of the Hubble constant, H 0 , when implemented on mock data, even if optimistic assumptions are made. We demonstrate explicitly that, as previously shown by multiple independent groups, the dark siren statistical method leads to an unbiased posterior when the method is applied to the data correctly. We highlight common sources of error possible to make in the generation of mock data and implementation of the statistical framework, including the mismodeling of selection effects and inconsistent implementations of the Bayesian framework, which can lead to a spurious bias. 

Abstract Detection of a gravitational-wave signal of non-astrophysical origin would be a landmark discovery, potentially providing a significant clue to some of our most basic, big-picture scientific questions about the Universe. In this white paper, we survey the leading early-Universe mechanisms that may produce a detectable signal—including inflation, phase transitions, topological defects, as well as primordial black holes—and highlight the connections to fundamental physics. We review the complementarity with collider searches for new physics, and multimessenger probes of the large-scale structure of the Universe.