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ABSTRACT Analysis of the genes retained in the minimized Mycoplasma JCVI-Syn3A genome established that systems that repair or preempt metabolite damage are essential to life. Several genes known to have such functions were identified and experimentally validated, including 5-formyltetrahydrofolate cycloligase, coenzyme A (CoA) disulfide reductase, and certain hydrolases. Furthermore, we discovered that an enigmatic YqeK hydrolase domain fused to NadD has a novel proofreading function in NAD synthesis and could double as a MutT-like sanitizing enzyme for the nucleotide pool. Finally, we combined metabolomics and cheminformatics approaches to extend the core metabolic map of JCVI-Syn3A to include promiscuous enzymatic reactions and spontaneous side reactions. This extension revealed that several key metabolite damage control systems remain to be identified in JCVI-Syn3A, such as that for methylglyoxal. IMPORTANCE Metabolite damage and repair mechanisms are being increasingly recognized. We present here compelling genetic and biochemical evidence for the universal importance of these mechanisms by demonstrating that stripping a genome down to its barest essentials leaves metabolite damage control systems in place. Furthermore, our metabolomic and cheminformatic results point to the existence of a network of metabolite damage and damage control reactions that extends far beyond the corners of it that have been characterizedmore »so far. In sum, there can be little room left to doubt that metabolite damage and the systems that counter it are mainstream metabolic processes that cannot be separated from life itself.« less

We combine JWST observations with Atacama Large Millimeter/submillimeter Array CO and Very Large Telescope MUSE Hαdata to examine off-spiral arm star formation in the face-on, grand-design spiral galaxy NGC 628. We focus on the northern spiral arm, around a galactocentric radius of 3–4 kpc, and study two spurs. These form an interesting contrast, as one is CO-rich and one CO-poor, and they have a maximum azimuthal offset in MIRI 21μm and MUSE Hαof around 40° (CO-rich) and 55° (CO-poor) from the spiral arm. The star formation rate is higher in the regions of the spurs near spiral arms, but the star formation efficiency appears relatively constant. Given the spiral pattern speed and rotation curve of this galaxy and assuming material exiting the arms undergoes purely circular motion, these offsets would be reached in 100–150 Myr, significantly longer than the 21μm and Hαstar formation timescales (both < 10 Myr). The invariance of the star formation efficiency in the spurs versus the spiral arms indicates massive star formation is not only triggered in spiral arms, and cannot simply occur in the arms and then drift away from the wave pattern. These early JWST results show that in situ star formation likelymore »occurs in the spurs, and that the observed young stars are not simply the “leftovers” of stellar birth in the spiral arms. The excellent physical resolution and sensitivity that JWST can attain in nearby galaxies will well resolve individual star-forming regions and help us to better understand the earliest phases of star formation.

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Abstract The CO-to-H 2 conversion factor ( α CO ) is critical to studying molecular gas and star formation in galaxies. The value of α CO has been found to vary within and between galaxies, but the specific environmental conditions that cause these variations are not fully understood. Previous observations on ~kiloparsec scales revealed low values of α CO in the centers of some barred spiral galaxies, including NGC 3351. We present new Atacama Large Millimeter/submillimeter Array Band 3, 6, and 7 observations of 12 CO, 13 CO, and C 18 O lines on 100 pc scales in the inner ∼2 kpc of NGC 3351. Using multiline radiative transfer modeling and a Bayesian likelihood analysis, we infer the H 2 density, kinetic temperature, CO column density per line width, and CO isotopologue abundances on a pixel-by-pixel basis. Our modeling implies the existence of a dominant gas component with a density of 2–3 × 10 3 cm −3 in the central ∼1 kpc and a high temperature of 30–60 K near the nucleus and near the contact points that connect to the bar-driven inflows. Assuming a CO/H 2 abundance of 3 × 10 −4 , our analysis yields α CO ∼more »0.5–2.0 M ⊙ (K km s −1 pc 2 ) −1 with a decreasing trend with galactocentric radius in the central ∼1 kpc. The inflows show a substantially lower α CO ≲ 0.1 M ⊙ (K km s −1 pc 2 ) −1 , likely due to lower optical depths caused by turbulence or shear in the inflows. Over the whole region, this gives an intensity-weighted α CO of ∼1.5 M ⊙ (K km s −1 pc 2 ) −1 , which is similar to previous dust-modeling-based results at kiloparsec scales. This suggests that low α CO on kiloparsec scales in the centers of some barred galaxies may be due to the contribution of low-optical-depth CO emission in bar-driven inflows.« less

The processes of star formation and feedback, regulating the cycle of matter between gas and stars on the scales of giant molecular clouds (GMCs; ∼100 pc), play a major role in governing galaxy evolution. Measuring the time-scales of GMC evolution is important to identify and characterize the specific physical mechanisms that drive this transition. By applying a robust statistical method to high-resolution CO and narrow-band H α imaging from the PHANGS survey, we systematically measure the evolutionary timeline from molecular clouds to exposed young stellar regions on GMC scales, across the discs of an unprecedented sample of 54 star-forming main-sequence galaxies (excluding their unresolved centres). We find that clouds live for about 1−3 GMC turbulence crossing times (5−30 Myr) and are efficiently dispersed by stellar feedback within 1−5 Myr once the star-forming region becomes partially exposed, resulting in integrated star formation efficiencies of 1−8 per cent. These ranges reflect physical galaxy-to-galaxy variation. In order to evaluate whether galactic environment influences GMC evolution, we correlate our measurements with average properties of the GMCs and their local galactic environment. We find several strong correlations that can be physically understood, revealing a quantitative link between galactic-scale environmental properties and the small-scale GMC evolution. Notably, the measured CO-visible cloudmore »lifetimes become shorter with decreasing galaxy mass, mostly due to the increasing presence of CO-dark molecular gas in such environment. Our results represent a first step towards a comprehensive picture of cloud assembly and dispersal, which requires further extension and refinement with tracers of the atomic gas, dust, and deeply embedded stars.

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Abstract We measure the low- J CO line ratios R 21 ≡ CO (2–1)/CO (1–0), R 32 ≡ CO (3–2)/CO (2–1), and R 31 ≡CO (3–2)/CO (1–0) using whole-disk CO maps of nearby galaxies. We draw CO (2–1) from PHANGS-ALMA, HERACLES, and follow-up IRAM surveys; CO (1–0) from COMING and the Nobeyama CO Atlas of Nearby Spiral Galaxies; and CO (3–2) from the James Clerk Maxwell Telescope Nearby Galaxy Legacy Survey and Atacama Pathfinder Experiment Large APEX Sub-Millimetre Array mapping. All together, this yields 76, 47, and 29 maps of R 21 , R 32 , and R 31 at 20″ ∼ 1.3 kpc resolution, covering 43, 34, and 20 galaxies. Disk galaxies with high stellar mass, log ( M ⋆ / M ⊙ ) = 10.25 – 11 , and star formation rate (SFR) = 1–5 M ⊙ yr −1 , dominate the sample. We find galaxy-integrated mean values and a 16%–84% range of R 21 = 0.65 (0.50–0.83), R 32 = 0.50 (0.23–0.59), and R 31 = 0.31 (0.20–0.42). We identify weak trends relating galaxy-integrated line ratios to properties expected to correlate with excitation, including SFR/ M ⋆ and SFR/ L CO . Within galaxies, we measure centralmore »enhancements with respect to the galaxy-averaged value of ∼ 0.18 − 0.14 + 0.09 dex for R 21 , 0.27 − 0.15 + 0.13 dex for R 31 , and 0.08 − 0.09 + 0.11 dex for R 32 . All three line ratios anticorrelate with galactocentric radius and positively correlate with the local SFR surface density and specific SFR, and we provide approximate fits to these relations. The observed ratios can be reasonably reproduced by models with low temperature, moderate opacity, and moderate densities, in good agreement with expectations for the cold interstellar medium. Because the line ratios are expected to anticorrelate with the CO (1–0)-to-H 2 conversion factor, α CO 1 − 0 , these results have general implications for the interpretation of CO emission from galaxies.« less

We present a rich, multiwavelength, multiscale database built around the PHANGS–ALMA CO (2 − 1) survey and ancillary data. We use this database to present the distributions of molecular cloud populations and subgalactic environments in 80 PHANGS galaxies, to characterize the relationship between population-averaged cloud properties and host galaxy properties, and to assess key timescales relevant to molecular cloud evolution and star formation. We show that PHANGS probes a wide range of kpc-scale gas, stellar, and star formation rate (SFR) surface densities, as well as orbital velocities and shear. The population-averaged cloud properties in each aperture correlate strongly with both local environmental properties and host galaxy global properties. Leveraging a variable selection analysis, we find that the kpc-scale surface densities of molecular gas and SFR tend to possess the most predictive power for the population-averaged cloud properties. Once their variations are controlled for, galaxy global properties contain little additional information, which implies that the apparent galaxy-to-galaxy variations in cloud populations are likely mediated by kpc-scale environmental conditions. We further estimate a suite of important timescales from our multiwavelength measurements. The cloud-scale freefall time and turbulence crossing time are ∼5–20 Myr, comparable to previous cloud lifetime estimates. The timescales formore »orbital motion, shearing, and cloud–cloud collisions are longer, ∼100 Myr. The molecular gas depletion time is 1–3 Gyr and shows weak to no correlations with the other timescales in our data. We publish our measurements online, and expect them to have broad utility to future studies of molecular clouds and star formation.

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ABSTRACT Feedback from massive stars plays a key role in molecular cloud evolution. After the onset of star formation, the young stellar population is exposed by photoionization, winds, supernovae, and radiation pressure from massive stars. Recent observations of nearby galaxies have provided the evolutionary timeline between molecular clouds and exposed young stars, but the duration of the embedded phase of massive star formation is still ill-constrained. We measure how long massive stellar populations remain embedded within their natal cloud, by applying a statistical method to six nearby galaxies at $20{-}100~\mbox{${\rm ~pc}$}$ resolution, using CO, Spitzer 24$\rm \, \mu m$, and H α emission as tracers of molecular clouds, embedded star formation, and exposed star formation, respectively. We find that the embedded phase (with CO and 24$\rm \, \mu m$ emission) lasts for 2−7 Myr and constitutes $17{-}47{{\ \rm per\ cent}}$ of the cloud lifetime. During approximately the first half of this phase, the region is invisible in H α, making it heavily obscured. For the second half of this phase, the region also emits in H α and is partially exposed. Once the cloud has been dispersed by feedback, 24$\rm \, \mu m$ emission no longer traces ongoing star formation, but remains detectable for anothermore »2−9 Myr through the emission from ambient CO-dark gas, tracing star formation that recently ended. The short duration of massive star formation suggests that pre-supernova feedback (photoionization and winds) is important in disrupting molecular clouds. The measured time-scales do not show significant correlations with environmental properties (e.g. metallicity). Future JWST observations will enable these measurements routinely across the nearby galaxy population.« less