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Immersive environments enable users to engage in embodied interaction, enhancing the sensemaking processes involved in completing tasks such as immersive analytics. Previous comparative studies on immersive analytics using augmented and virtual realities have revealed that users employ different strategies for data interpretation and text-based analytics depending on the environment. Our study seeks to investigate how augmented and virtual reality influences sensemaking processes in quantitative immersive analytics. Our results, derived from a diverse group of participants, indicate that users demonstrate comparable performance in both environments. However, it was observed that users exhibit a higher tolerance for cognitive load in VR and travel further in AR. Based on our findings, we recommend providing users with the option to switch between AR and VR, thereby enabling them to select an environment that aligns with their preferences and task requirements. 

Immersive Analytics (IA) and consumer adoption of augmented reality (AR) and virtual reality (VR) head-mounted displays (HMDs) are both rapidly growing. When used in conjunction, stereoscopic IA environments can offer improved user understanding and engagement; however, it is unclear how the choice of stereoscopic display impacts user interactions within an IA environment. This paper presents a pilot study that examines the impact of stereoscopic display choice on object manipulation and environmental navigation using consumeravailable AR and VR HMDs. Our observations indicate that the display can impact how users manipulate virtual content and how they navigate the environment. 

Elicitation studies have become a popular method of participatory design. While traditionally used to examine unimodal gesture interactions, elicitation has started being used with other novel interaction modalities. Unfortunately, there has been no work that examines the impact of referent display on elicited interaction proposals. To address that concern this work provides a detailed comparison between two elicitation studies that were similar in design apart from the way that participants were prompted for interaction proposals (i.e., the referents). Based on this comparison the impact of referent display on speech and gesture interaction proposals are each discussed. The interaction proposals between these elicitation studies were not identical. Gesture proposals were the least impacted by referent display, showing high proposal similarity between the two works. Speech proposals were highly biased by text referents with proposals directly mirroring text-based referents an average of 69.36% of the time. In short, the way that referents are presented during elicitation studies can impact the resulting interaction proposals; however, the level of impact found is dependent on the modality of input elicited. 

Interacting in stereoscopic head mounted displays can be difficult. There are not yet clear standards for how interactions in these environments should be performed. In virtual reality there are a number of well designed interaction techniques; however, augmented reality interaction techniques still need to be improved before they can be easily used. This dissertation covers work done towards understanding how users navigate and interact with virtual environments that are displayed in stereoscopic head-mounted displays. With this understanding, existing techniques from virtual reality devices ... (For more, see "View full record.") 

Although epithelial-mesenchymal transition (EMT) is a common feature of fibrotic lung disease, its role in fibrogenesis is controversial. Recently, aberrant basaloid cells were identified in fibrotic lung tissue as a novel epithelial cell type displaying a partial EMT phenotype. The developmental origin of these cells remains unknown. To elucidate the role of EMT in the development of aberrant basaloid cells from the bronchial epithelium, we mapped EMT-induced transcriptional changes at the population and single-cell levels. Human bronchial epithelial cells grown as submerged or air-liquid interface (ALI) cultures with or without EMT induction were analyzed by bulk and single-cell RNA-Sequencing. Comparison of submerged and ALI cultures revealed differential expression of 8,247 protein coding (PC) and 1,621 long noncoding RNA (lncRNA) genes and revealed epithelial cell-type-specific lncRNAs. Similarly, EMT induction in ALI cultures resulted in robust transcriptional reprogramming of 6,020 PC and 907 lncRNA genes. Although there was no evidence for fibroblast/myofibroblast conversion following EMT induction, cells displayed a partial EMT gene signature and an aberrant basaloid-like cell phenotype. The substantial transcriptional differences between submerged and ALI cultures highlight that care must be taken when interpreting data from submerged cultures. This work supports that lung epithelial EMT does not generate fibroblasts/myofibroblasts and confirms ALI cultures provide a physiologically relevant system to study aberrant basaloid-like cells and mechanisms of EMT. We provide a catalog of PC and lncRNA genes and an interactive browser ( https://bronc-epi-in-vitro.cells.ucsc.edu/ ) of single-cell RNA-Seq data for further exploration of potential roles in the lung epithelium in health and lung disease.