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National data indicates that engineering students are less likely than students in other academic disciplines to seek professional help for their mental health distress. Without professional intervention, mental health symptoms can worsen and become more challenging to treat. Therefore, this study uses a quantitative approach to investigate the beliefs that first-year engineering students hold about seeking mental health treatment and the influence of these beliefs on their intention to seek professional help. This study addresses the following research questions: 1) Which factors are most strongly associated with first-year engineering students’ intention to seek mental health treatment? 2) What beliefs about the outcomes of professional mental healthcare are most predictive of students’ intention to seek treatment? This study used a self-report survey instrument that employed the Integrated Behavioral Model (IBM) as an empirically supported theoretical framework to identify the beliefs that most accurately predict behavior. In December 2021, a survey was conducted in the first-year engineering program at a large public university with a predominantly White population (n = 452). The self-report survey instrument included measures of mental health help-seeking intention, attitude, perceived norm, personal agency, and outcome beliefs guided by the IBM. Respondents exhibited high scores on scales measuring their attitude towards seeking help, perceived control, and self-efficacy. This suggests that, on average, first-year engineering students had positive perceptions of their seeking help, felt in control of their decisions to seek help, and were confident in their ability to seek help. Students had lower scores for perceived norms, meaning they were less likely to believe that seeking help was supported by those who are important to them. Additionally, less than half of the students indicated they would intend to seek help if they experienced mental health distress. Students’ perception that others would expect them to seek help (i.e., their perceived norm injunctive) was the strongest predictor of intention to seek help, followed by their attitude toward seeking help. The specific outcome beliefs that were negatively correlated with intention to seek help were that seeking help would: 1) go against the expectations of the engineering community, 2) be a sign of weakness or an admission of defeat, and 3) result in poor treatment or discrimination from the mental health professional. Conversely, the outcome beliefs most positively correlated with intention were that seeking help would: 1) help me feel supported, 2) help me improve my coping skills, 3) make me feel better, 4) help me find a solution to my problem, and 5) help me gain a better understanding of my mental health concern. The findings of this study offer valuable insights into the beliefs of first-year engineering students towards seeking professional treatment for mental health concerns. These findings will inform the development of targeted interventions to improve help-seeking for mental health. 

The purpose of this workshop is to introduce instructional and disciplinary tenure-track STEM faculty to high-quality qualitative research design in order to explore their intellectual curiosity around STEM education. We will do so using the ProQual approach, a methodologically unencumbered and widely accessible way of thinking about qualitative research design that was deployed and refined over the last three years as part of the NSF-funded ProQual Institute for Research Methods. This workshop will be conducted by STEM faculty who have graduated from the ProQual Institute, who are culturally sensitive to the challenges faced by disciplinary STEM faculty. Leveraging a propagation model of effecting academic change, these workshop leaders will also serve as a community of practice to help workshop participants move their educational research ideas forward during and after the workshop. 

FePO₄NPs are of special interest in food fortification and biomedical imaging because of their biocompatibility, high bioavailability, magnetic property, and superior sensory performance that do not cause adverse organoleptic effects. These characteristics are desirable in drug delivery as well. Here, we explored the FePO₄nanoparticles as a delivery vehicle for the anticancer drug, doxorubicin, with an optimum drug loading of 26.81% ± 1.0%. This loading further enforces the formation of Fe³⁺doxorubicin complex resulting in the formation of FePO₄-DOX nanoparticles. FePO₄-DOX nanoparticles showed a good size homogeneity and concentration-dependent biocompatibility, with over 70% biocompatibility up to 80 µg/mL concentration. Importantly, cytotoxicity analysis showed that Fe³⁺complexation with DOX in FePO₄-DOX NPs enhanced the cytotoxicity by around 10 times than free DOX and improved the selectivity toward cancer cells. Furthermore, FePO₄NPs temperature-stabilize RNA and support mRNA translation activity showing promises for RNA stabilizing agents. The results show the biocompatibility of iron-based inorganic nanoparticles, their drug and RNA loading, stabilization, and delivery activity with potential ramifications for food fortification and drug/RNA delivery.

 

Although cells of mushroom-producing fungi typically contain paired haploid nuclei (n + n), mostArmillaria gallicavegetative cells are uninucleate. As vegetative nuclei are produced by fusions of paired haploid nuclei, they are thought to be diploid (2n). Here we report finding haploid vegetative nuclei inA. gallicaat multiple sites in southeastern Massachusetts, USA. Sequencing multiple clones of a single-copy gene isolated from single hyphal filaments revealed nuclear heterogeneity both among and within hyphae. Cytoplasmic bridges connected hyphae in field-collected and cultured samples, and we propose nuclear migration through bridges maintains this nuclear heterogeneity. Growth studies demonstrate among- and within-hypha phenotypic variation for growth in response to gallic acid, a plant-produced antifungal compound. The existence of both genetic and phenotypic variation within vegetative hyphae suggests that fungal individuals have the potential to evolve within a single generation in response to environmental variation over time and space.

 

Cellular aggregation in plant suspension cultures directly affects the accumulation of high value products, such as paclitaxel fromTaxus. Through application of mechanical shear by repeated, manual pipetting through a 10 ml pipet with a 1.6 mm aperture, the mean aggregate size of aTaxusculture can be reduced without affecting culture growth. When a constant level of mechanical shear was applied over eight generations, the sheared population was maintained at a mean aggregate diameter 194 μm lower than the unsheared control, but the mean aggregate size fluctuated by over 600 μm, indicating unpredictable culture variability. A population balance model was developed to interpret and predict disaggregation dynamics under mechanical shear. Adjustable parameters involved in the breakage frequency function of the population balance model were estimated by nonlinear optimization from experimentally measured size distributions. The optimized model predictions were in strong agreement with measured size distributions. The model was then used to determine the shear requirements to successfully reach a target aggregate size distribution. This model will be utilized in the future to maintain a culture with a constant size distribution with the goal of decreasing culture variability and increasing paclitaxel yields.