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We report a minimalist gaseous sulfonyl-chloride-derived reagent for multicomponent bioconjugation with amine, phenol, or aniline reagents to afford urea or carbamate products. With the utilization of a gas-phase reagent for a reaction mediated by metal ions, a variety of biologically relevant molecules, such as saccharide, poly(ethylene glycol), fluorophore, and affinity tag, can be efficiently cross-linked to the N terminus or lysine side-chain amines on natural polypeptides or proteins.more » « lessFree, publicly-accessible full text available July 29, 2025
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Abstract Peptide cyclization has dramatic effects on a variety of important properties, enhancing metabolic stability, limiting conformational flexibility, and altering cellular entry and intracellular localization. The hydrophilic, polyfunctional nature of peptides creates chemoselectivity challenges in macrocyclization, especially for natural sequences without biorthogonal handles. Herein, we describe a gaseous sulfonyl chloride derived reagent that achieves amine–amine, amine–phenol, and amine–aniline crosslinking through a minimalist linchpin strategy that affords macrocyclic urea or carbamate products. The cyclization reaction is metal‐mediated and involves a novel application of sulfine species that remains unexplored in aqueous or biological contexts. The aqueous method delivers unique cyclic or bicyclic topologies directly from a variety of natural bioactive peptides without the need for protecting‐group strategies.
Free, publicly-accessible full text available July 14, 2025 -
Free, publicly-accessible full text available May 11, 2025
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Abstract Underwater Distributed Acoustic Sensing (DAS) utilizes optical fiber as a continuous sensor array. It enables high‐resolution data collection over long distances and holds promise to enhance tsunami early warning capabilities. This research focuses on detecting infragravity and tsunami waves associated with earthquakes and understanding their origin and dispersion characteristics through frequency‐wavenumber domain transformations and beamforming techniques. We propose a velocity correction method based on adjusting the apparent channel spacing according to water depth to overcome the challenge of detecting long‐wavelength and long‐period tsunami signals. Experimental results demonstrate the successful retrieval of infragravity and tsunami waves using a subsea optical fiber in offshore Oregon. These findings underscore the potential of DAS technology to complement existing infragravity waves detection systems, enhance preparedness, and improve response efforts in coastal communities. Further research and development in this field are crucial to fully utilize the capabilities of DAS for enhanced tsunami monitoring and warning systems.
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Abstract Peptide cyclization has dramatic effects on a variety of important properties, enhancing metabolic stability, limiting conformational flexibility, and altering cellular entry and intracellular localization. The hydrophilic, polyfunctional nature of peptides creates chemoselectivity challenges in macrocyclization, especially for natural sequences without biorthogonal handles. Herein, we describe a gaseous sulfonyl chloride derived reagent that achieves amine–amine, amine–phenol, and amine–aniline crosslinking through a minimalist linchpin strategy that affords macrocyclic urea or carbamate products. The cyclization reaction is metal‐mediated and involves a novel application of sulfine species that remains unexplored in aqueous or biological contexts. The aqueous method delivers unique cyclic or bicyclic topologies directly from a variety of natural bioactive peptides without the need for protecting‐group strategies.
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Abstract During the past few years, distributed acoustic sensing (DAS) has become an invaluable tool for recording high-fidelity seismic wavefields with great spatiotemporal resolutions. However, the considerable amount of data generated during DAS experiments limits their distribution with the broader scientific community. Such a bottleneck inherently slows down the pursuit of new scientific discoveries in geosciences. Here, we introduce PubDAS—the first large-scale open-source repository where several DAS datasets from multiple experiments are publicly shared. PubDAS currently hosts eight datasets covering a variety of geological settings (e.g., urban centers, underground mines, and seafloor), spanning from several days to several years, offering both continuous and triggered active source recordings, and totaling up to ∼90 TB of data. This article describes these datasets, their metadata, and how to access and download them. Some of these datasets have only been shallowly explored, leaving the door open for new discoveries in Earth sciences and beyond.more » « less